JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
January 2018
U-P07 (NP)

Signalment: (JPC #CG-5) Adult cynomolgus monkey (Macaca fascicularis)

HISTORY:  Incidental finding in an adult cynomolgus monkey (Macaca fascicularis)

HISTOPATHOLOGIC DESCRIPTION:  Kidney, with perirenal fibrovascular tissue:   Expanding the perirenal fibrovascular tissue, creating numerous cavities (parasite migration tracts), and abutting the renal capsule are several cross sections of a 1mm diameter adult filarid nematodes  The nematode is characterized by a smooth 4-5 um cuticle; coelomyarian  musculature; low, broad-based lateral chords; a pseudocoelom; a large, glandular, lumenless esophagus; an small intestine lined by uninucleated low cuboidal cells; and a uterus containing 2-3 um microfilaria.  Multifocally, surrounding the nematode there is abundant edematous fibrous connective tissue  with small caliber vessels (granulation tissue), admixed with hemorrhage, erythrocyte-laden macrophages (erythrophagocytosis), eosinophilic fibrillar material (fibrin), moderate numbers of eosinophils, epithelioid macrophages, fewer lymphocytes, plasma cells, neutrophils, and rare multinucleate giant cells.  Diffusely, the renal cortical interstitium is mildly expanded by eosinophilic homogenous material (edema), admixed with low numbers of lymphocytes, plasma cells, and neutrophils. Multifocally within the cortex, lymphatics are markedly ectatic, tubules have attenuated or lost epithelium, and many tubules contain low to moderate numbers of viable and degenerate neutrophils admixed with eosinophilic, proteinaceous material and a small amount of eosinophilic cellular and karyorrhectic debris (granular casts).  Multifocally within the subcapsular space are few, up to 500 um in diameter, lymphoid nodules.

Adrenal gland (within fibrovascular tissue):  No significant lesions.

MORPHOLOGIC DIAGNOSIS: 

1. Fibrovascular tissue, perirenal:  Retroperitonitis, eosinophilic and granulomatous, focally extensive, moderate with granulation tissue, hemorrhage and few filarial nematodes, etiology consistent with Edesonfilaria malayensis, cynomolgus monkey (Macaca fascicularis), primate.

2. Kidney: Nephritis, tubulointerstitial, multifocal, mild with cellular casts

ETIOLOGIC DIAGNOSIS:  Retroperitoneal edesonfilariasis

CAUSE:  Edesonfilaria malayensis

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:  

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

Other Old World Monkey filarid nematodes:

New World Monkey filarid nematodes:

REFERENCES:

  1. Abbott DP, Majeed SK. A survey of parasitic lesions in wild‑caught, laboratory‑maintained primates: Rhesus, Cyanomologus, and Baboon. Vet Pathol. 1984;21:198‑207.
  2. Gardiner CH, Poynton SL. An Atlas of Metazoan Parasites in Animal Tissues. Washington, DC: American Registry of Pathology; 1999:35,39. 
  3. Lowenstine LJ, Osborn KG. Respiratory system diseases of nonhuman primates. In: Abee CR, Mansfield K, Tardif S, Morris T, eds. Nonhuman Primates in Biomedical Research: Diseases. 2. 2nd ed. Oxford, UK: Elsevier; 2012:466.
  4. Narama I, Miura K, Tsuruta M, et al. Microfilarial granulomas in the spleens of wild‑caught Cynomolgus monkeys. Vet Pathol. 1985;22:355‑362.
  5. Strait K, Else JG, Eberhard ML. Parasitic diseases of nonhuman primates. In: Abee CR, Mansfield K, Tardif S, Morris T, eds. Nonhuman Primates in Biomedical Research: Diseases. 2. 2nd ed. Oxford, UK: Elsevier; 2012:227,231,241.


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