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Read-Only Case Details Reviewed: Oct 2008

JPC SYSTEMIC PATHOLOGY
RESPIRATORY SYSTEM
September 2020
P-P07

Signalment (JPC #1642875):  Cat

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Lung:  Effacing and replacing approximately 30% of the pulmonary parenchyma are multifocal to coalescing inflammatory nodular aggregates composed of numerous macrophages and fewer lymphocytes, plasma cells, neutrophils, and eosinophils with abundant fibrous connective tissue and minimal hemorrhage, fibrin, and edema.  These inflammatory nodules surround an adult trematode and trematode eggs.  The adult trematode is 2x3 mm, has a 40um thick spiny tegument, and a spongy parenchyma that contains numerous subtegumental vitellaria with eosinophilic globular yolk material.  The trematode is surrounded by increased amounts of fibrovascular tissue oriented perpendicularly to small caliber blood vessels (granulation tissue). Trematode eggs are 80 x 100um and have a 1‑3um thick, yellow, anisotropic shell.  In less affected areas there are pigment laden macrophages, lymphoid aggregates, and hemorrhage, fibrin, and edema. Multifocally, bronchial and bronchiolar lumina are filled with sloughed epithelial cells, low numbers of macrophages, neutrophils, lymphocytes, and plasma cells.  There is multifocal bronchiolar and alveolar smooth muscle hypertrophy, as well as hyperplasia of peribronchial mucous glands.  Multifocally the tunica media of small and medium blood vessels is thickened by smooth muscle hypertrophy (medial hypertrophy), and there is endothelial hypertrophy and vacuolation.  The pleura is thickened 2-3 times normal by lymphocytes, plasma cells, macrophages, fibrous connective tissue, and hypertrophic (reactive) cuboidal mesothelial cells.  

MORPHOLOGIC DIAGNOSIS:  Lung:  Pneumonia, granulomatous, multifocal, nodular, chronic, moderate, with fibrosis, pleuritis, and adult trematodes and eggs, etiology consistent with Paragonimus sp., breed unspecified, feline.

ETIOLOGIC DIAGNOSIS:  Pulmonary paragonimiasis

CAUSE:  Paragonimus kellicotti 

GENERAL DISCUSSION: 

PATHOGENESIS:

Life Cycle:

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Bowman DD. Helminths. In: Georgis’ Parasitology for Veterinarians. 10th ed, St. Louis, MO: WB Saunders; 2014:410-412.
  2. Caswell JL, Williams KJ. Respiratory System. In: Maxie ME, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. 6th ed. Vol 2, Philadelphia, PA: Elsevier; 2016:591.
  3. Gardiner CH, Poyton SL. An Atlas of Metazoan Parasites in Animal Tissue.  Washington, DC: Armed Forces Institute of Pathology; 1990:46-48.
  4. Lopez A, Martinson SA. Respiratory system, mediastinum, and pleurae. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St Louis, MO: Elsevier; 2017:548,551, 556.
  5. Urquhart GM, Armour J, Duncan JL, Dunn AM, et al. Veterinary Parasitology. 2nd ed. Blackwell Science LTD: Oxford, England; 1996:116-117.


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