AFIP SYSTEMIC PATHOLOGY

JPC SYSTEMIC PATHOLOGY

SPECIAL SENSES

MAY 2015

S-P02

 

Signalment (AFIP# 1754374):  Unknown age and gender New Zealand white rabbit 

 

HISTORY:  A New Zealand white rabbit had crusting, erythema and intense pruritus in both ears.

 

MORPHOLOGIC DESCRIPTION:  Haired skin and ear pinna:  Diffusely, the epidermis is covered by a thick, up to 3 mm crust consisting of loosely arranged lamellations of orthokeratotic and parakeratotic hyperkeratosis, entrapped degenerative inflammatory cells, numerous arthropod adults and eggs and colonies of 1-2 um diameter basophilic cocci.  Mites are approximately 300 um wide with a chitinous exoskeleton, occasional spines, striated musculature, jointed appendages, a digestive tract and ovary.  Within the ovary is a large, developing egg characterized by numerous eosinophilic globules.  Eggs are oval, 60 um in diameter with a thin, 2-3 um, pale eosinophilic shell and contain numerous 2-3 um basophilic, round structures and variably-sized eosinophilic globules (yolk material).  Diffusely, the epidermis is moderately hyperplastic with acanthosis, spongiosis and prominent rete ridge formation.  Multifocally, the underlying superficial dermis is infiltrated by low numbers of heterophils and macrophages.  Diffusely, apocrine glands are ectatic.

 

MORPHOLOGIC DIAGNOSIS:  Haired skin and ear pinna:  Hyperkeratosis, orthokeratotic and parakeratotic, diffuse, severe, with mild heterophilic dermatitis, epidermal hyperplasia, and numerous superficial intracorneal adult mites and eggs, etiology consistent with Psoroptes cuniculi, New Zealand white rabbit, lagomorph.

 

ETIOLOGIC DIAGNOSIS: Psoroptic otitis externa; psoroptic otoascariasis

 

CAUSE:  Psoroptes cuniculi

 

CONDITION:  Ear canker; psoroptic mange; psoroptic scabies; ear mange

 

GENERAL:

·         P. cuniculi is a non-burrowing, obligate parasite that is the most common and costly ectoparasite disease of rabbits

·         Psoroptic mites live on skin covered with hair or wool or in the ears

·         In rabbits, the mites are almost exclusively found on the inner epithelial surface of the pinna (concha) of the ear 

·         Severe cases of ear canker have been reported to be fatal

·         There is no zoonotic or vector significance associated with psoroptic mange

 

PATHOGENESIS:

·         All stages of the life cycle are completed on the skin surface in less than three weeks

·         Highly contagious and transmitted by direct contact

·         Initially, mites feed on lipids from the stratum corneum

·         Inflammatory response to saliva or fecal material produces intense pruritus and secondary, self-inflicted trauma from scratching; mites then feed on released serum and hemoglobin produced in the epidermal crust

·         Scratching spreads mites and predisposes animal to secondary bacterial infections on the face, neck and legs

 

TYPICAL CLINICAL FINDINGS:

·         Intense pruritic dermatitis; head shaking; ear scratching

·         Malodorous discharge  

·         Ears are painful

·         Occasional lesions on the face, head, neck, limbs, abdomen and back

 

TYPICAL GROSS FINDINGS:

·         Hyperemia and edema of the pinna

·         Tan to brown crusty exudate along the inside of the pinna often filling the ear canal

·         Crusts form on the inner pinna and removal of the debris and exudate reveals moist, erythematous skin

 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

·         Marked parakeratotic hyperkeratosis with numerous mites and eggs present in a keratin crust

·         Superficial dermatitis with eosinophils, mast cells and lymphocytes

·         Mites are large and oval shaped (400 x 700 um) with a chitinous exoskeleton, jointed appendages, striated muscle, simple intestine with cuboidal or columnar epithelium and females have ova containing brightly eosinophilic globular material (yolk/developing eggs)

 

ADDITIONAL DIAGNOSTIC TESTS:

·         Ear swab or skin scraping

·         Mite is large enough to be seen with the unaided eye

·         Single most important characteristic is long, 3-segmented pedicels with terminal caruncle

 

DIFFERENTIAL DIAGNOSIS:

·         Notoedres cati:  Smaller size (400 um in length); rear legs that do not extend beyond the margin of the body;  sucker on a short unsegmented stalk;  burrowing mite

·         Cheyletiella parasitovorax (fur mite):  Smaller than N. cati (380 um in length); large curved palpal hooks adjacent to piercing mouthparts; can transmit rabbit myxoma virus

·         Sarcoptes scabiei:  Located within the stratum corneum rather than on the surface

·         Listrophorus gibbus:  High incidence of asymptomatic infections in domestic rabbits

·         Trichophyton mentagrophytes:  Dermatophyte in rabbits; hyperkeratotic dermatitis

 

COMPARATIVE PATHOLOGY:

·         Notoedres cati:  Scabies of the cat; effects the head and ears (particularly the margin); causes severe pruritus and is highly contagious

·         P. cuniculi has also been reported in the ears of horses, goats, sheep, donkeys, mules and deer

·         Other psoroptic mites and their primary hosts include:

o   P. ovis ‑ body mite of sheep (one of the worst parasites of sheep); also affects cattle; reportable disease in sheep and cattle in most states

o   P. equi ‑ body mite of horses (indistinguishable from P. cuniculi)

o   P. natalensis ‑ body mite of cattle (P. ovis also reported)

o   P. cervinus ‑ ear canal mite of bighorn sheep

o   P. hippous ‑ ear canal mite of horses

·         Knemidocoptes mutans (chickens) or K. pilae (budgerigar) – proliferative and hyperkeratotic dermatitis of the legs and beak/face

 

References:

1.     Bowman DD, Lynn RC, Eberhard ML. Arthropods. In: Bowman DD, Lynn RC, Eberhard ML, eds. Georgis’ Parasitology for Veterinarians. 8th ed. St. Louis, MO: Saunders; 2003:63-76. 

2.     Gardiner CH, Poynton SL. Morphological characteristics of arthropods in tissue section. In: Gardiner CH, Poynton SL, eds. An Atlas of Metazoan Parasites in Animal Tissues. Washington, DC: Armed Forces Institute of Pathology; 1999:56-58.

3.     Ginn PE, Mansell JEKL, Rakich PM. Skin and appendages. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 1. 5th ed. Philadelphia, PA: Elsevier Saunders; 2007:719-727.

4.     Miller WH, Griffin CE, Campbell KL. Dermatoses of exotic small mammals. In: Miller WH, Griffin CE, Campbell KL, eds. Muller and Kirk's Small Animal Dermatology. 7th ed. St. Louis, MO: Elsevier Mosby; 2013:848-849.

5.     Percy DH, Barthold SW. Rabbit. In: Percy DH, Barthold SW, eds. Pathology of Laboratory Rodents and Rabbits. 3rd ed. Ames, IA: Blackwell Publishing Ltd; 2007:295-298.

 

Wienandt 2015


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