JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

September 2017

P-P08 (NP)

 

Signalment (JPC #1669224):  A 5-year-old female poodle

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Lung:  The is diffuse consolidation of the section.  Areas of consolidation are characterized by filling of alveoli with numerous viable and degenerate neutrophils, foamy macrophages, few lymphocytes, plasma cells, and moderate numbers of reactive fibroblasts admixed with hemorrhage, fibrin, necrotic debris, and numerous cross and tangential sections of cestode larvae.  Larvae are up to 150 um in diameter with a thick outer tegument surrounding a loose parenchymatous matrix, an invaginated unarmed scolex with suckers, and numerous calcareous corpuscles.  Alveolar septa are frequently fragmented and discontinuous, replaced by cellular debris (septal necrosis) or are variably expanded by fibrin, few lymphocytes and plasma cells with occasional type II pneumocyte hyperplasia.  Multifocally there is loss of differential staining with retention of pulmonary architecture (coagulative necrosis).  Multifocally, bronchiolar lumina contain and exudate of hemorrhage, fibrin, neutrophils, and macrophages.  The pleura is mildly expanded by edema and fibrin with few macrophages, neutrophils, lymphocytes, plasma cells, reactive fibroblasts, and hemorrhage. 

MORPHOLOGIC DIAGNOSIS:  Lung:  Pneumonia, neutrophilic and histiocytic, multifocal to coalescing, severe, with hemorrhage, necrosis, pleuritis and numerous cestode larvae, poodle, canine,

ETIOLOGIC DIAGNOSIS:  Pulmonary mesocestodiasis

ETIOLOGY: Mesocestoides spp.

GENERAL DISCUSSION:

PATHOGENESIS & LIFE CYCLE:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

Parasitic peritonitis or pleuritis in a dog:

COMPARATIVE PATHOLOGY:

References:

  1. Caruso KJ, et al. Cytologic diagnosis of peritoneal cestodiasis in dogs caused by Mesocestoides sp. Vet Clin Pathol. 2003;32(2):50-60.
  2. Eberhard ML. Histopathological diagnosis. In: Bowman DD, ed. Georgis’ Parasitology for Veterinarians. 10th ed. Philadelphia, PA: WB Saunders; 2014: 416
  3. Gardiner CH, et al. An Atlas of Metazoan Parasites in Animal Tissues. Washington, DC: Armed Forces Institute of Pathology; 1999:50-55.
  4. Gelberg HB. Alimentary system and the peritoneum, omentum, mesentery, and peritoneal cavity. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby Elsevier; 2016: 339
  5. Jacobson ER, et al. Infectious Diseases and Pathology of Reptiles: Color Atlas and Text. Boca Raton, FL: CRC Press; 2007: 634
  6. Patten PK, et al. Cestode infection in 2 dogs: cytologic findings in liver and a mesenteric lymph node. Vet Clin Pathol. 2013;42(1):103-108.
  7. Uzal FA, et al. Alimentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals, Vol 2, 6th ed. St. Louis, MO: Elsevier; 2016: 223


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