JPC SYSTEMIC PATHOLOGY
SPECIAL SENSES SYSTEM
MAY 2018
S-N01 (NP)

SIGNALMENT (AFIP # 2051261): Tissue from a 9-year-old ox

HISTORY: None

HISTOPATHOLOGIC DESCRIPTION:

  1. Conjunctiva: Arising from the mucosal epithelium, effacing the subepithelial connective tissue and extending to all margins is an unencapsulated, densely cellular, infiltrative neoplasm composed of polygonal cells arranged in islands, cords, and anastomosing trabeculae a moderately dense fibrovascular stroma.  Neoplastic cells mature in an disorganized manner which multifocally includes a granular cell layer and neolastic cells occasionally surround concentric lamellations of keratin (keratin pearls). Neoplastic cells have variably distinct cell borders, a moderated amount of eosinophilic cytoplasm which is often vacuolated, round to oval nuclei with coarsely clumped chromatin, up to three multifocally distinct nucleoli, and a mitotic rate of 2 per 10 HPF. Neoplastic cells exhibit widespread scattered individual cell necrosis. Many lymphocytes, plasma cells, macrophages and neutrophils admixed with hemorrhage, fibrin, and edema diffusely infiltrate the fibrovascular stroma and extend into the superficial conjunctival subepithelial connective tissue. There are large areas of necrosis often associated with the keratinized surface, and multifocally few vessels contain fibrin thrombi. Focally the epithelium is eroded or ulcerated and replaced by a serocellular crust, and subepithelial lymphatics are diffusely dilated. 
  2. Lymph node, site unspecified: No significant lesions.

MORPHOLOGIC DIAGNOSES:

  1. Conjunctiva: Squamous cell carcinoma, breed unspecified, bovine.
  2. Lymph node, site unspecified: No significant lesions.

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

Gross

Microscopic:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Beckwith-Cohen B, Teixeira LBC, Ramos-Vara JA, et al. Squamous Papillomas of the Conjunctiva in Dogs: A Condition Not Associated With Papillomavirus Infection. Vet Pathol. 2015;52(4):676-680.
  2. Carvalho T, Vala H, Pinto C et al. Immunohistochemical Studies of Epithelial Cell Proliferation and p53 Mutation in BovineOcularSquamousCell Vet Pathol. 2005;42: 66-73.
  3. Dubielzig RR. Tumors of the eye. In: Meuten DJ, ed. Tumors in Domestic Animals. 5th ed. Ames, IA: Iowa State Press; 2017:893-895.
  4. Grahn BH, Peiffer RL. Veterinary Ophthalmic Pathology. In: Gelatt KN, Gilger BC, Kern TJ, eds. Veterinary Ophthalmology. 5th ed. Baltimore, MD: Lippincott Williams & Wilkins; 2013:503-508.
  5. Labelle P. The Eye. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO:Mosby; 2017:1295-1296; 1299.
  6. Maggs DJ. Diseases of the eye. In: Smith BP, ed. Large Animal Internal Medicine. 4 th ed. St. Louis, MO: Mosby Elsevier; 2009:1301.
  7. Vitiella V, Burrai GP, Argus M, et al. Ovis aries Papillomavirus 3 in Ovine Cutaneous Squamous Cell Carcinoma. Vet Pathol. 2017 Sep:54(5):775-782.
  8. Whitaker CJG, Gelatt KN, Wilkie DA. Food animal ophthalmology. In: Gelatt KN, ed. Veterinary Ophthalmology. 3 rd ed. Baltimore, MD: Lippincott Williams & Wilkins; 1999:1140-51.
  9. Wilcock BP: Special Senses. In: Maxie MG, ed. Jubb, Kennedy and Palmers Pathology of Domestic Animals, Vol 1. 6th ed. Philadelphia, PA: Elsevier-Saunders; 2016:479-480.
  10. Wilcock B, Dubielzig RR, Render JA. Histological classification of ocular and otic tumors of domestic animals. In: Schulman FY, ed. World Health Organization International Histological Classification of Tumors of Domestic Animals. 2 nd series, vol. IX, Washington, DC:Armed Forces Institute of Pathology; 2002:16, 18.


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