JPC SYSTEMIC PATHOLOGY
CARDIOVASCULAR SYSTEM
April 2019
C-M10

Signalment (JPC #2457059):  A 9-year-old male castrated domestic shorthair cat

HISTORY:  This cat presented with acute onset posterior paresis

HISTOPATHOLOGIC DESCRIPTION:  Heart:  The left ventricular free wall and interventricular septum are thickened up to 8 mm and the right ventricular wall is 2 mm thick.  Multifocally the left ventricular free wall, papillary muscle, and interventricular septum are characterized by increased interstitial fibrous connective tissue that surrounds, separates, and occasionally replaces often degenerate cardiomyocytes (interstitial fibrosis).  There are occasional foci up to 1mm in diameter characterized by loss of cardiomyocytes with replacement by moderate amounts of collagen and rare adipocytes (replacement fibrosis).  Adjacent to these foci, myofibers are often pale, swollen, and vacuolated (degenerate).  Diffusely cardiomyocytes are enlarged 2-3 times normal with abundant eosinophilic fibrillar cytoplasm and a large vesicular nucleus (hypertrophy).  Multifocally cardiomyocytes are irregularly arranged in right-angle branching or radiating "pinwheel" patterns (myofiber disarray).  The tunica media of occasional myocardial small arteries and arterioles is expanded by hypertrophic smooth muscle cells (medial hypertrophy).

MORPHOLOGIC DIAGNOSIS:  Heart, myocardium:  Fibrosis, interstitial, multifocal, moderate, with myofiber hypertrophy, disarray, degeneration, and loss, and occasional myocardial arterial medial hypertrophy, Domestic Shorthair, feline.

CONDITION:  Hypertrophic cardiomyopathy

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURE:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

Other Cardiomyopathies in Cats:

COMPARATIVE PATHOLOGY:

Cardiomyopathies in Other Species:

REFERENCES:

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