JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
October 2018
D-T12 (NP)

SIGNALMENT (JPC #2289065):  4-month-old Shorthorn calf

HISTORY:  Severe weight loss, anorexia, and photophobia.  Diet included grain, lucerne hay, and grazed reclaimed land.  Was in very poor body condition, icteric, and had crusty excoriations around the eyes and muzzle. Gross lesions included a mild accentuation of the lobular pattern of the liver and gallbladder distention.

HISTOPATHOLOGIC DESCRIPTION:  Liver: Hepatocytes are diffusely enlarged up to 100 um in diameter (megalocytosis) and compress adjacent sinusoids.  They often contain abundant pale, finely vacuolated cytoplasm (glycogen-type degeneration) or few discrete clear vacuoles which peripheralize the nucleus (lipid degeneration). They have vesiculate nuclei up to 30 um in diameter with 1-3 prominent nucleoli, and are frequently multinucleated.  Rarely, there are randomly distributed necrotic foci characterized by individualized or lost hepatocytes with replacement by cellular and karyorrhectic debris admixed with few lymphocytes, macrophages, neutrophils and hemorrhage. Periportal connective tissue is expanded by numerous small bile duct profiles (biliary ductular reaction) admixed with hyperplastic oval cells.

MORPHOLOGIC DIAGNOSIS:  Liver: Hepatocellular degeneration, diffuse, moderate, with megalocytosis, biliary ductular reaction, oval cell hyperplasia, and rare hepatocellular necrosis, Shorthorn, bovine.

ETIOLOGIC DIAGNOSIS:  Lantana hepatotoxicosis

CAUSE:  Lantadene A, B, or C, or icterogenin of the plant Lantana camara

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

TYPICAL ULTRASTRUCTURAL FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY: 

REFERENCES:

  1. Brown DL, Van Wettere AJV, Cullen JM. Hepatobiliary system and exocrine pancreas. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:450.
  2. Cullen JM, Stalker MJ. Liver and Biliary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier Ltd; 2016:293-294, 338.
  3. Hargis AM, Myers S. The integument. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:1063.
  4. Robinson WF, Robinson NA. Cardiovascular system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier Ltd; 2016:36.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |