JPC SYSTEMIC PATHOLOGY
CARDIOVASCULAR SYSTEM
April 2019
C-M01 (NP)

Signalment (JPC# 1532051):  465-day-old female Balb/c mouse

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Heart:  Multifocally and extensively within the myocardium and the subepicardial right ventricular wall, cardiac myocytes are swollen and vacuolated with loss of sarcoplasmic detail (degeneration), or hypereosinophilic, shrunken and fragmented with pyknotic or karyolytic nuclei (necrosis).  Separating, surrounding, and replacing degenerate and necrotic cardiac myofibers, there is abundant basophilic granular material (mineral) and increased collagen (fibrosis) with moderate numbers of hypertrophied fibroblasts.  There are scattered lymphocytes and plasma cells within the areas of mineralization and multiple areas of osseous metaplasia.  Occasionally, adjacent cardiomyocytes have large vesiculate nuclei.

Thymus:  Essentially normal tissue.

MORPHOLOGIC DIAGNOSIS:  Heart, myocardium:  Mineralization, degeneration, and necrosis, multifocal, moderate, with fibrosis, Balb/c mouse, rodent.

CONDITION:  Dystrophic cardiac calcinosis (DCC)

CONDITION SYNONYM:  Dystrophic mineralization

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSES:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Berndt A, et al. Phenotypic characterization of the KK/HIJ inbred mouse strain. Vet Pathol. 2014;51(4): 846-857.
  2. Craig LE, Dittmer KE, Thompson KG. Bones and joints. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th St. Louis, MO: Elsevier; 2016:89.
  3. Han S, Garner MM. Soft tissue mineralization in captive 2-toed sloths. Vet Pathol. 2016;53(3)659-665.
  4. Percy DH, Barthold SW. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: Blackwell Publishing; 2016: 93-94, 242.
  5. Robinson WF, Robinson NA. Cardiovascular system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th St. Louis, MO: Elsevier; 2016: 30, 60-61.
  6. Rothenburger JL, Himsworth CG, Treuting PM, Leighton FA. Survey of cardiovascular pathology in wild urban Rattus norvegicus and Rattus rattus. Vet Pathol. 2015;52(1):201-208.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |