JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
October 2018
D-P13

Signalment (JPC #2317370):  Cow

History:  None

HISTOPATHOLOGIC DESCRIPTION:  Abomasum, fundus:  Diffusely the mucosa is thickened up to 2mm by elongated and occasionally tortuous gastric glands and hyperplastic gastric pits. Multifocally the lamina propria is moderately expanded by lymphocytes, plasma cells and eosinophils, and there are occasional dense aggregates of lymphocytes within the mucosa (lymphoid nodules).. Focally within the deep mucosa is 100um diameter tangential and cross sections of adult Trichostrongyle nematodes. These are characterized by a 10um-thick cuticle, multiple longitudinal cuticular ridges, platymyarian/meromyarian musculature, a pseudocoelom, lateral chords, a large digestive tract composed of few multinucleated cells, and reproductive tract containing eosinophilic globular material. Hyperplastic gastric pits are lined by numeorus mucous neck cells that exhibit a loss of polarity, pile up to 5 cell layers thick, and have frequent mitotic figures (mucous neck cell hyperplasia). Multifocally, numerous mucous neck cells preplace gastric gland parietal cells (mucous neck cell metaplasia). Gastric pits and less frequently gastric glands are multifocally dilated and the dilated gastric pits are lined by attenuated epithelium and contain cellular and karyorrhectic debris admixed with eosinophilis.

MORPHOLOGIC DIAGNOSIS:  Abomasum:  Abomasitis, proliferative and eosinophilic, chronic, multifocal, moderate, with parietal cell loss and mucous neck cell hyperplasia and metaplasia and adult Trichostrongyle nematodes, etiology consistent with Ostertagia ostertagi, breed unspecified, bovine.                                                                                         

ETIOLOGIC DIAGNOSIS:  Abomasal ostertagiasis

CAUSE:  Ostertagia ostertagi

GENERAL DISCUSSION:

LIFE CYCLE: 

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS: 

For gross lesions:

COMPARATIVE PATHOLOGY:

Trichostrongyle stomach worms in other species:

REFERENCES:

  1. Gardiner CH, Poynton SL. An Atlas of Metazoan Parasites in Animal Tissues. Washington, DC: Armed Forces Institute of Pathology; 1999:26.
  2. Gelberg HB. Alimentary system and the peritoneum, omentum, mesentery, and peritoneal cavity. In: Zachary JF, McGavin MD, eds. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Elsevier Mosby; 2017:400.
  3. Uzal FA, Plattner BL, Hostetter JM. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. Philadelphia, PA: Elsevier Ltd; 2016:205-207.


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