JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
December 2017
U-M03

SIGNALMENT (JPC # 1574396, U-M03a):  Cat, breed not specified

HISTORY:  Incidental finding in a cat

HISTOPATHOLOGIC DESCRIPTION:  Kidney:  Multifocally, approximately 60% of the cortex and medulla are expanded by numerous 1 to 8 mm diameter cysts that are lined by a single layer or multiple layers of attenuated or cuboidal epithelial cells, and distended by clear space or filled with eosinophilic homogenous material (proteinaceous fluid), which occasionally contains acicular cholesterol clefts. Multifocally within the adjacent parenchyma, cysts compress adjacent ducts and tubules with mild to moderate atrophy and loss. Diffusely, remaining cortical tubules are mildly ectatic and often lined by atrophic or degenerate epithelium. Multifocally, medullary tubules are lined by attenuated or hypertrophied epithelium and often surround a lumen with eosinophilic proteinaceous material, hemorrhage, and/or few lymphocytes. Multifocally, the interstitium is mildly expanded by fibrous connective tissue admixed with variable numbers of lymphocytes and plasma cells, and rare deposits of basophilic, granular mineral. Diffusely, the capsular surface is irregular. 

MORPHOLOGIC DIAGNOSIS:  Kidney:  Cysts, multiple, with chronic, moderate lymphoplasmacytic interstitial nephritis and tubular atrophy, loss, and ectasia, breed not specified, feline.

SIGNALMENT (AFIP # U-M03b):  Goldfish

HISTORY:  The goldfish appeared less agile than other fish in the school and had difficulty with buoyancy.

LIGHT MICROSCOPIC DESCRIPTION:  Kidney, metanephros:  Multifocally the renal parenchyma is markedly expanded by multiple 0.5 to 4 mm diameter cysts that are lined by attenuated epithelial cells and distended by clear space.  Cysts compress the adjacent renal parenchyma with mild atrophy and loss of ducts and tubules.  Multifocally, remaining tubules are moderately ectatic and occasionally contain granular to cellular debris. 

MORPHOLOGIC DIAGNOSIS:  Kidney, metanephros:  Cysts, multiple, with moderate tubular ectasia and atrophy, goldfish, piscine.

CONDITION:  Polycystic kidney

GENERAL DISCUSSION: 

In glomerulocystic disease, cysts only develop in Bowman's space (occasionally seen in stillborn foals and Collie dogs)

PATHOGENESIS: 

(1) Autosomal dominant inheritance (similar to the adult form in humans)

(2) Autosomal recessive inheritance (similar to the congenital form in humans)

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

DIFFERENTIAL DIAGNOSIS: 

COMPARATIVE PATHOLOGY:  

Associated lesions per mouse model: only the Pkd 1l1-/- mouse model had polycystic kidney disease (PKD)

 

Mouse model

Dpcd/poll-/-

Nme7-/-

Pkd 1/1-/-

TTLL1

 

 

 

 

 

Infertility

+

-

-

+

Hydrocephalus

+

+

-

-

Polycystic kidney

-

-

+

-

Sinusitis

+

+

-

+

Laterality (Sinus inversus)

+

+

+

-

 

REFERENCES: 

  1. Alpers CE, Chang A. The Kidney. In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2015:945-948.
  2. Breshears MA, Confer AW. Urinary system. In: McGavin MD, Zachry JF, eds. Pathological Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2016:643-644.
  3. Cianciolo RE, Mohr FC. Urinary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. Philadelphia, PA: Elsevier Ltd; 2016:394-396.
  4. Ferguson HW. Systemic Pathology of Fish. In: Ferguson HW, ed. A Text and Atlas of Comparative Tissue Responses in Diseases of Teleosts. Ames, IA: Iowa State University Press; 1989:45.
  5. Herder V, Kummrow M, Leeb T, et al. Polycystic Kidneys and GM2 Gangliosidosis-Like Disease in Neonatal Springboks (Antidorcas marsupialis). Vet Pathol. 2015; 52(3):543-552.
  6. Percy DH, Barthold SW. Mouse. In: Percy DH, Barthold SW, eds. Pathology of Laboratory Rodents and 4th ed. Ames, IA: Blackwell Publishing; 2016:103.
  7. Reimschuessel R, Ferguson HW. Kidney. In: Ferguson HW, ed. Systemic pathology of Fish. 2nd London, UK: Scotian Press; 2006: 100.
  8. Roberts, RJ, Rodger HD. The Pathophysiology and Systematic pathology of teleosts. In: Roberts RJ, ed. Fish Pathology. 4th ed. Ames, IA: Blackwell publishing; 2012:113.
  9. Scanlon MC, da Silva TF, Aquino LC, Carneiro FT, et al. Touchdown polymerase chain reaction detection of polycystic kidney disease and laboratory findings in different cat populations. Journal of Veterinary Diagnostic Investigation. 2014; 26(4):542-546.
  10. Vogel P, Read R, Hansen GM, Freay LC, Zambrowicz BP, Sands AT. Situs Inversus in Dpcd/Poll–/–, Nme7–/–, and Pkd1l1–/– Vet Pathol. 2010;47(1):120-131.


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