JPC SYSTEMIC PATHOLOGY

INTEGUMENTARY SYSTEM

November 2016

I-V05

 

Signalment (JPC #2070431): Chicken, breed and age unspecified

HISTORY:  This bird had multiple raised proliferative lesions over its body.

HISTOPATHOLOGIC DESCRIPTION:  Feathered skin:  Multifocally, the epidermal and follicular epithelium is disrupted and thickened up to ten times normal thickness by extensive areas of hyperplasia with long rete ridges and thick bands of an eosinophilic coagulum that attaches to or replaces the epithelium.  Multifocally there are large areas of coagulative necrosis within the epidermis that extend into the dermis and are characterized by loss of differential staining, karryorhectic and cellular debris, with retention of tissue architecture with many degenerate heterophils and bacterial colonies.  There is marked thickening of the stratum spinosum with markedly swollen keratinocytes (ballooning degeneration) containing a 15-30 um eosinophilic intracytoplasmic viral inclusion body (Bollinger body).  Within the areas of necrosis and infiltrating into the dermis and subcutis are numerous viable and degenerate heterophils with macrophages, lymphocytes, and plasma cells admixed with abundant fibrin, hemorrhage, and edema.  Similar inflammatory cells infiltrate into and surround portions of the panniculus carnosus where the muscle fibers are multifocally necrotic with brightly eosinophilic shrunken cytoplasm with pyknotic nuclei.

MORPHOLOGIC DIAGNOSIS:  Feathered skin and subcutis:  Dermatitis, necrotizing and proliferative, subacute, multifocal, marked, with ballooning degeneration, and eosinophilic intracytoplasmic viral inclusion bodies, breed unspecified, chicken.

ETIOLOGICAL DIAGNOSIS:  Avipoxviral dermatitis

CAUSE:  Avian poxvirus 

CONDITION:  Fowl pox

GENERAL:

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS:

Cutaneous form:

Diphtheritic form:

TYPICAL GROSS FINDINGS:

Cutaneous form: 

Diphtheritic form: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

Cutaneous pox:

Diphtheritic pox:

COMPARATIVE PATHOLOGY: 

REFERENCES: 

  1. Boulianne M. Viral diseases. In: Avian Disease Manual. 7th ed. Jacksonville, FL: American Association of Avian Pathologists, Inc.; 2013: 46-49.
  2. Campbell TW. Infectious agents. In: Exotic Animal Hematology and Cytology. 4th ed. Ames, IA; John Wiley & Sons, Inc.;2015:323-324.
  3. Cheville NF, Lehmkuhl H. Cytopathology of viral diseases. In: Cheville NF, ed. Ultrastructural Pathology, 2nd ed. Ames, IA: Wiley-Blackwell; 2009: 319-327.
  4. Jarmin S, Manvell R, Gough RE, Laidlaw SM, Skinner MA. Avipoxvirus phylogenetics: Identification of a PCR length polymorphism that discriminates between the two major clades. J Gen Virol. 2006; 87: 2191-2201.
  5. Krone O, Essbauer S, Wibbelt G, Rudolph M, Cough RE. Avipoxvirus infection in peregrine falcons (Falco peregrinus) from a reintroduction programme in Germany. Vet Rec. 2004; 154: 110-113.
  6. Schmidt RE, Reavill DR, Phalen DN. Special sense organs. In: Pathology of Pet and Aviary Birds. 1st ed. Ames, IA: Iowa State Press; 2003:197-201.
  7. Tripathy DN, Reed WM.   In: Swayne DE, ed.  Diseases of Poultry. 13th ed.  Ames, IA: Wiley-Blackwell; 2013: 333-349.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |