JPC SYSTEMIC PATHOLOGY
Musculoskeletal System
March 2019
M-M02

Signalment: (JPC #2314367):  Angus calf

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Long bone, longitudinal section:  Extending from both the epiphyseal and metaphyseal surfaces of physis, are increased numbers of irregular, enlarged, anastomosing trabeculae of immature woven bone (primary spongiosa), that often have retained cartilage cores with retained hypertrophic chondrocytes, which fill the marrow cavity and extend into the diaphysis.  Trabeculae form horizontal connections to adjacent trabeculae and contain a central cartilaginous core surrounded by variably thick layers of osteoid and mineralized bone.  There are markedly reduced numbers of both osteoclasts and osteoblasts. Diffusely, there is an overall decrease in hematopoietic elements within medullary spaces and they often contain small amounts of loose fibrous connective tissue. Cortical bone thickens advancing toward the diaphysis.

MORPHOLOGIC DIAGNOSIS:  Long bone:  Persistent primary spongiosa with osteoclastopenia, failure of chondroclasis and diffuse medullary osteosclerosis (osteopetrosis), Angus, bovine.

CONDITION:  Bovine congenital osteopetrosis

SYNONYMS:  Marble bone disease, Albers-Schonberg disease

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. O’Toole D, Swist S, Steadman L, Johnson GC. Neuropathology and craniofacial lesions of osteopetrotic red Angus calves. Vet Pathol 2012; 49(5):746-754.
  2. Nuss K, Spiess A, Hilbe M, Sterr K, Reiser M, Matis U. Transient benign osteopetrosis in a calf persistently infected with bovine virus diarrhea virus. Vet Comp Orthop Traumatol 2005; 18(2):100-104.
  3. Rajan I, Read R, Small DL, Perrard J, Vogel P. An alternative splicing variant in Clcn7-/- mice prevents osteopetrosis but not neural and retinal degeneration. Vet Pathol 2011; 48(3):663-675.
  4. Teitelbaum SL. Bone resorption by osteoclasts. 2000; 289:1504-1508.
  5. Craig LE, Dittmer KE, Thompson KG. Bones and joints. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA: Elsevier; 2016:50-52.
  6. Webb BT, Norrdin RW, Smirnova NP, et al. Bovine viral diarrhea virus cyclically impairs long bone trabecular modeling in experimental persistently infected fetuses. Vet Pathol. 2012;49(6):930-940.
  7. Van Wesenbeeck L, Odgren PR, Coxon FP, et al. Involvement of PLEKHM1 in osteclastic vesicular transport and osteopetrosis in incisors absent rats and humans. J Clin Invest 2007; 117(4):919-930.
  8. Olson EJ, Carlson CS. Bones, joints, tendons, and ligaments. In: McGavin MD, Zachary JF, eds. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:973.


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