JPC SYSTEMIC PATHOLOGY
MUSCULOSKELETAL SYSTEM
MARCH 2019 M-B02 (NP)

Signalment (JPC #2064900):  Young chicken

HISTORY:  This chicken was experimentally injected with Staphylococcus aureus.

HISTOPATHOLOGIC DESCRIPTION:  Tibia:  Multifocally, metaphyseal vessels extending into the hypertrophic zone are dilatedand contain moderate numbers of viable and degenerate heterophils admixed with eosinophilic cellular and karyorrhectic debris (necrosis) and fibrin; similar inflammatory cells and necrotic debris extend into and disrupt the adjacent physeal cartilage multifocally, with loss of matrix and chondrocytes.  Spaces between primary spongiosa are multifocally filled with heterophils, fibrin and hemorrhage, which occasionally extends into the matrix of individual trabeculae in areas of osteoclastic and chondroclastic resporption.  There is a 3X4 mm area within the hypertrophic cartilage zone where the cartilage matrix has lost basophilic staining and is pale, and chondrocytes in lacunae are bright eosinophilic and shrunken (necrosis)(focally extensive infarct). Diffusely the synovial membrane is expanded by few heterophils, macrophages, and fewer lymphocytes, admixed with fibrin, edema, cellular debris, and congested vessels.  The joint space and adjacent adipose tissue contain abundant heterophils and fewer macrophages admixed with sloughed synoviocytes.

MORPHOLOGIC DIAGNOSIS: 

  1. Tibia, metaphysis:  Osteomyelitis, heterophilic, acute, multifocal, moderate, with arthritis, chicken, avian.
  2. Synovial membrane: Synovitis, heterophilic and lymphohistocytic, subacute, diffuse, mild. 

ETIOLOGIC DIAGNOSIS:  Bacterial osteomyelitis and synovitis

CAUSE:  Staphylococcus aureus

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Andreasen CB. Staphylococcosis. In: Swayne DE, et al, eds. Diseases of Poultry. 13th ed. Ames, IA: John Wiley & Sons, Inc.; 2013: 971--977.
  2. Borst LB,Suyemoto MMKeelara SDunningan SEGuy JSBarnes HJ. A chicken embryo lethality assay for pathogenic Enterococcus cecorum. Avian Dis. 2014; 58(2):244-8.
  3. Corrand L, Lucas MN, Douet JY, et al. A case of unilateral periorbital cellulitis and mandibular osteomyelitis in a turkey flock. Avian Dis. 2012; 56(2):427-431.
  4. Craig LE, Dittmer KE, Thompson K. Bones and joints: In: Maxie MG, ed. Jubb Kennedy and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. St. Louis, MO: Elsevier; 2016:97-103.
  5. Fulton RL. Bacterial diseases.. In: Boulianne M, et al, eds. Avian Disease Manual. 7th Jacksonville, FL: AAAP, Inc.; 2013:134-136.
  6. Hinckley L, Ewalt D, Schlievert PM, et al. Brucella vertebral osteomyelitis with intercurrent fatal Staphylococcus aureus toxigenic enteritis in a bottle nose dolphin (Tursiops truncates). J Vet Diagn Invest. 2011; 23(4):845-851.
  7. Johansen LK, Koch J, Frees D, et al. Pathology and biofilm formation in a porcine model of staphylococcal osteomyelitis. J Comp Pathol. 2012; 147(2-3):343-353.
  8. Lawson GW. Etiopathogenesis of mandibulofacial and maxillofacial abscesses in mice. Comp Med. 2010; 60(3):200-204.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |