September 2015

Signalment (JPC #2423644):  30-year-old male rhesus macaque

HISTORY:  Exposed to whole body penetrating proton radiation 28 years previously. Severe progressive weight loss was noted (3.4 kg over 6 months) before death.

HISTOPATHOLOGIC DESCRIPTION (D-N05a):  Duodenum: Transmurally infiltrating and effacing the mucosa, lamina propria, submucosa, tunica muscularis, and serosa, projecting into the duodenal lumen, and compressing the adjacent exocrine pancreas, is an unencapsulated, infiltrative, poorly demarcated, moderately cellular neoplasm composed of cuboidal to columnar cells arranged in tubules and acini supported by a moderately dense desmoplastic stroma.  Neoplastic cells have indistinct borders, moderate amounts of granular eosinophilic cytoplasm, irregularly round to oval nuclei with finely stippled chromatin, and 1 to 2 distinct nucleoli.  Neoplastic cells often lack polarity, and pile up to 4 cell layers thick.  The mitotic rate is regionally variable, between 2 to 6 per individual HPF.  Tubules are often filled with sloughed neoplastic cells, necrotic debris, and occasionally degenerate and non-degenerate neutrophils. Multifocally throughout the fibrous stroma, the lamina propria, and the pancreas, there are aggregates of lymphocytes and plasma cells and fewer macrophages, as well as ectatic lymphatics (edema).  Within a focally extensive area of the exocrine pancreas, there is loss of acinar cells (atrophy), a marked decrease in the zymogen granules of remaining acinar cells (degeneration), and increased numbers of small pancreatic ducts (tubular complexes). Multifocally, pancreatic ducts are ectatic.


  1. 1. Duodenum:  Adenocarcinoma, tubular, Rhesus macaque (Macaca mulatta), nonhuman primate.
  2. Pancreas: Atrophy, acinar, focally extensive, moderate, with tubular complexes (regeneration)

Signalment (JPC #2460108):  Ten-year-old cotton top tamarin (Saguinus oedipus)

HISTORY:  Presented thin and dehydrated and had been treated numerous times for colitis beginning at 6.5 years of age.

HISTOPATHOLOGIC DESCRIPTION (D-N05b):  Colon: Multifocally effacing the mucosa, submucosa, and subjacent gut associated lymphoid tissue is a moderately cellular, unencapsulated, infiltrative, poorly circumscribed neoplasm composed of cuboidal to columnar cells arranged in disorganized cords and tubules supported by a fine fibrous stroma.  Neoplastic cells have indistinct cell borders, moderate amounts of lightly basophilic, granular to vacuolated cytoplasm, and oval nuclei with finely stippled chromatin and 1 to 2 variably distinct nucleoli. Mitoses average 2 per HPF, and there is moderate anisocytosis and anisokaryosis. Neoplastic cells often pile up to 4 cell layers thick. Multifocally, occasional neoplastic cells are rounded with a single clear cytoplasmic vacuole that peripheralizes the nucleus (signet ring cells). Neoplastic tubules are often dilated and contain a mixture of neutrophils, mucin, sloughed epithelial cells, and cellular debris. Subjacent lymphatics are ectatic (edema). Multifocally, scattered throughout the neoplasm and expanding adjacent lamina propria are plasma cells, lymphocytes, and fewer neutrophils. Diffusely within adjacent tissue, the mucosal epithelium is uneven with papillary hyperplasia.  Crypts are multifocally mildly ectatic and contain crypt abscesses. 


  1. 1.  Colon: Adenocarcinoma, cotton-top tamarin (Saguinus oedipus), nonhuman primate.
  2. Colon: Colitis, proliferative, chronic-active, diffuse, moderate, with crypt hyperplasia and crypt abscesses.

CONDITION:  Intestinal/colonic adenocarcinoma










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