JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

August 2017

P-B15

 

Signalment (JPC #1492950):  Australorp chick   

HISTORY:  Two chicks became sick shortly after the new owner moved the brooder.  Gross pathology included a yellow, solid, 3 mm nodule in the right lung and an abscessed umbilicus that was adhered to the gut.

HISTOPATHOLOGIC DESCRIPTION:  Lung:  Affecting approximately 40% of the section, filling the lumina and obscuring or effacing the walls of secondary bronchi, parabronchi, and respiratory atria, there is a mucinous exudate composed of numerous foamy macrophages, viable and degenerate heterophils, sloughed necrotic epithelial cells, fewer multinucleated cells, lymphocytes and plasma cells, fibrin, hemorrhage, and edema. Respiratory epithelium is either hyperplastic and up to 3 cell layers thick, attenuated, discontinuous, or necrotic, with shrunken hypereosinophilic cytoplasm and pyknotic nuclei, with occasional sloughing.  Adjacent air capillaries are effaced by eosinophilic cellular and karyorrhectic debris (lytic necrosis) and similar inflammatory cells, fibrin, edema, and hemorrhage.  Multifocally, perivascular and interlobular septa are moderately expanded by fibrin, increased clear space and ectatic lymphatics (edema), and low numbers of similar inflammatory cells.  Diffusely, blood vessels are moderately congested.

MORPHOLOGIC DIAGNOSIS:  Lung:  Pneumonia, necrotizing, subacute, focally extensive, marked, Australorp, chicken.

ETIOLOGIC DIAGNOSIS:  Pulmonary salmonellosis

CAUSE:  Salmonella Pullorum

ETIOLOGY SYNONYMS:  Salmonella enterica serovar Gallinarum biovar Pullorum; Salmonella enterica ssp. enterica serovar Gallinarum-Pullorum

CONDITION:  Pullorum disease

GENERAL DISCUSSION:

 PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

Chicks 

Adults 

TYPICAL GROSS FINDINGS:

Chicks 

Adults

TYPICAL LIGHT MICROSCOPIC FINDINGS:

Chicks

Adults

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

Histologic lesions

Gross lesions:

COMPARATIVE PATHOLOGY:

References:

  1. Anderson LA, Miller DA, Trampel DW. Epidemiological investigation, cleanup and eradication of pullorum disease in adult chickens and ducks in two small-farm flocks. Avian Dis. 2006;50(1):142-147.
  2. Barrow PA, Jones MA, Smith AL, Wigley P. The long view: Salmonella — the last forty years. Avian Pathol. 2012;41(5):413-420.
  3. Barrow PA, Neto OCF. Pullorum disease and fowl typhoid—new thoughts on old diseases: a review. Avian Pathol. 2011;40(1):1-13.
  4. Batista DFA, de Freitas Neto OC, de Almeida AM, et al. Molecular identification of Salmonella enterica Enterica serovar Gallunarum biovars Gallinarum and Pullorum by a duplex PCR assay. J Vet Diagn Invest. 2016;28(4): 419-422.
  5. Batista DFA, de Freitas Neto OC, Lopez PD, et al. Polymerase chain reaction assay based on ratA gene allows differentiation between Salmonella enterica enterica serovar Gallinarum biovars Gallinarum and Pullorum. J Vet Diagn Invest. 2013;25(2):259-262.
  6. Chappell L, Kaiser P, Barrow P, Jones MA, Johnston C, Wigley P. The immunobiology of avian systemic salmonellosis. Vet Immunol Immunopathol. 2009;128(1-3):53-59.
  7. Fulton RM, Boulianne M. Salmonellosis. In: Boulianne M, ed. Avian Disease Manual. 7th Jacksonville, FL: The American Association of Avian Pathologists; 2013.
  8. Henderson SC, Bounous DI, Lee MD. Early events in the pathogenesis of avian salmonellosis. Infect Immun. 1999;67(7):3580-3586.
  9. Shivaprasad HL, Barrow PA. Pullorum disease and fowl typhoid. In: Saif YM, ed. Diseases of Poultry. 13th ed. Ames, IA: Blackwell Publishing; 2008:678-693.


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