JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
October 2018
D-T02

Signalment (JPC #704742):  6-month-old Duroc pig.

History:  This pig received a standard ration, which contained 9% cottonseed meal for 50 days prior to death.  The cottonseed meal contained 0.25% gossypol.

HISTOPATHOLOGIC Description:  Liver:  Diffusely there is centrilobular to midzonal (submassive) necrosis characterized by disruption and loss of normal hepatic chord architecture with hepatocytes that are shrunken and hypereosinophilic nuclei with pyknotic and/or karryorhectic nuclei (necrosis) or that are lost and replaced by abundant hemorrhage and small amounts of cellular and karyorrhectic debris. Adjacent sinusoids are dilated up to 3x normal, congested and filled with eosinophilic beaded material (fibrin).  There are few degenerate periportal hepatocytes with pale swollen cytoplasm, which are rimmed by a thin layer of viable hepatocytes at the limiting plate.  Within portal areas there are few lymphocytes and plasma cells and rare eosinophils.  Kupffer cells and hepatocytes often contain dark brown globular pigment (hemosiderin).

Morphologic Diagnosis:  Liver: Necrosis, centrilobular to midzonal (submassive), acute, diffuse, with moderate congestion and hemorrhage, Duroc, porcine.

Etiologic Diagnosis:  Toxic hepatic necrosis

Etiology:  Gossypol intoxication

General DISCUSION:

Pathogenesis:

typical Clinical Signs:

Typical Gross Findings:

Typical LIGHT Microscopic Findings:

Differential Diagnosis:

For centrilobular necrosis

COMPARATIVE PATHOLOGY:

References:

  1. Constable PD, Hinchcliff KW, Done SH, Grunberg W. Veterinary Medicine, A Textbook of the Diseases of Cattle, Sheep, Pigs, Goats and Horses. 11th ed. St. Louis, MO: Elsevier; 2017:2206-2207.
  2. Cooper BJ, Valentine BA. Muscle and tendon. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th St. Louis, MO: Elsevier; 2016:220.
  3. Cullen JM, Stalker MJ. Liver and Biliary System. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th St. Louis, MO: Elsevier; 2016:330-343.
  4. Ensley SM, Osweiler GD. Toxic minerals, chemicals, plants, and gases. In: Karriker LA, Ramirez A, Schwartz KJ, Stevenson EW, eds. Diseases of Swine. 10th Ames, IA: John Wiley & Sons; 2012:963-964.
  5. Miller LM, Gal A. Cardiovascular system and lymphatic vessls. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Elsevier; 2017:593.
  6. Nicholson, SS. Cottonseed toxicity. In: Gupta RC, ed. Veterinary Toxicology, Basic and Clinical Principles. 1st ed. New York, NY: Academia Press; 2007:926-928.
  7. Valentine BA. Skeletal muscle. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Elsevier; 2017:925,945.
  8. Uzal FA, Puschner B, Tahara JM, Nordhausen RW. Gossypol toxicosis in a dog consequent to ingestion of cottonseed bedding. JVDI 2005; 17:626-629.


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