JPC SYSTEMIC PATHOLOGY

INTEGUMENT SYSTEM

September 2016

I-M27

Signalment (JPC #2185555):  A horse

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Haired skin:  There are multifocal sub-basilar clefts, up to 2.5 mm long, separating the epidermis from the dermis.  Clefts contain small amounts of eosinophlic fluid (serum) and low numbers of erythrocytes and small, clear vacuoles. Occasionally, less affected areas of the dermal-epidermal junction are also separated by multiple small clear vacuoles (subepidermal vacuolar alteration).  There is focally extensive, mild epidermal hyperplasia with mild acanthosis and spongiosis.  Multifocally, there is mild parakeratotic hyperkeratosis with multiple intracorneal pustules containing degenerate neutrophils.  The underlying superficial and perivascular dermis is mildly expanded by low to moderate numbers of neutrophils, lymphocytes and plasma cells admixed with low numbers of reactive fibroblasts and mild fibrosis.  Multifocally there is mild apocrine gland and follicular ectasia.

MORPHOLOGIC DIAGNOSIS:  Haired skin:  Vesicles, subepidermal, multiple, with intracorneal pustules and mild lymphoplasmacytic interface and perivascular dermatitis, breed unspecified, equine.

ETIOLOGIC DIAGNOSIS:  Immune-mediated dermatopathy

CONDITION:  Bullous pemphigoid

GENERAL DISCUSSION: 

 PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS:

 TYPICAL GROSS FINDINGS: 

 TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

Noninfectious vesicular and bullous formation:

COMPARATIVE PATHOLOGY: 

REFERENCES:

  1. Eden KB, Peterson A, Payne HR, Corapi WV, Mansell J, Rodrigues Hoffman A. Congenital dystrophic epidermolysis bullosa (DEB) in sprage dawley rats: a case series. Vet Dermatol 2013;27:122-e34.
  2. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Skin Diseases of the Dog and Cat. 2nd ed. Ames, IA: Blackwell; 2005: 27-30.
  3. Hashimoto T, Ishii N, Ohata C, Furumura M. Pathogenesis of epidermolysis bullosa acquisita, an autoimmune subepidermal bullous disease. J Pathol. 2012;228(1):1-7.
  4. Hiroyasu S, Ozawa T, Kobayashi H, et al. Bullous pemphigoid IgG Induces BP180 internalization via a macropinocytic pathway. Am J Pathol. 2013;182(3):828-840.
  5. Mauldin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. St. Louis, MO: Elsevier; 2016: 533-534, 603-604.
  6. Mirsky ML, Singleton W, Olivry T. "Have you seen this?" Spontaneous cutaneous vesicular disease in Yucatan minipigs. Tox Pathol. 2000;28(2):357-358.
  7. Olivery T, Bizikova P, Dunston SM, et al. Clinical and immunological heterogeneity of canine subepidermal blistering dermatoses with anti-laminin- 332 (laminin-5) auto-antibodies. Vet Dermatol. 2010;21(4):345-357.
  8. Scott DW, Miller WH. Equine Dermatology. 2nd ed. Maryland Heights, MO: Elsevier Saunders; 2011: 83.


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