JPC SYSTEMIC PATHOLOGY
HEMOLYMPHATIC SYSTEM
April 2018
H-V09 (NP)

Signalment (JPC # 1810441):  A 7-week-old male cocker spaniel

HISTORY:  This dog had diarrhea and died. 

HISTOPATHOLOGIC DESCRIPTION:  Spleen:  There is diffuse, marked lymphoid depletion within the white pulp.  Periarteriolar sheaths contain moderately to markedly decreased numbers of mature lymphocytes with scattered large lymphocytes that are separated by abundant eosinophilic fibrillar to finely granular material (collapsed sinusoids/reticuloendothelial matrix and fibrin).  There is a mild increase in tingible-body macrophages that often contain eosinophilic cellular and karyorrhectic debris, and few lymphocytes with faded nuclei and karyolysis (lymphocytolysis).  Within the red and white pulp there are few megakaryocytes (EMH).

Liver: Perivascular areas and sinusoids are mildly distended by pale eosinophilic homogneous fluid (edema).

MORPHOLOGIC DIAGNOSIS:  Spleen:  Lymphoid depletion, diffuse, marked, with lymphocytolysis and stromal collapse, cocker spaniel, canine.

Liver: Edema, multifocal, mild.

ETIOLOGIC DIAGNOSIS:  Parvoviral splenic lymphoid depletion

CAUSE:  Canine parvovirus-2 (CPV-2) 

GENERAL DISCUSSION:

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

Peyer's patch necrosis and hemorrhage

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY: 

REFERENCS:

  1. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: Wiley-Blackwell; 2016:17-19, 122-124, 175-176.
  2. Boes KM, Durham AC. Bone marrow, blood cells, and the lymphoid/lymphatic system. In: Zachary JF, Pathologic Basis of Veterinary Disease. 6th ed. St Louis, MO: Elsevier; 2017:801.
  3. Ford J, McEndaffer L, Renshaw R, Molesan A, Kelly K. Parvovirus infection is associated with myocarditis and myocardial fibrosis in young dogs. Vet Pathol. 2017;54(6):964-971.
  4. Greene CE, Decaro N. Canine viral enteritis. In: Greene CE, ed. Infectious Diseases of the Dog and Cat. 4th ed. St. Louis MO: Elsevier Saunders.  2012: 67-76.
  5. Mauldin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. St. Louis, MO: Elsevier; 2016:628.
  6. McEndaffer L, Molesan A, Erb H, Kelly K. Feline panleukopenia virus is not associated with myocarditis or endomyocardial restrictive cardiomyopathy in cats. Vet Pathol. 2017;54(4):669-675.
  7. Miller LM, Gal A. Cardiovascular system and lymphatic vessels. In: Zachary JF, Pathologic Basis of Veterinary Disease. 6th ed. St Louis, MO: Elsevier; 2017:609.
  8. Palya VJ. Parvovirus infections of waterfowl. In: Swayne DE, ed. Diseases of Poultry. 13th ed. Ames, IA: John Wiley & Sons, Inc; 2013:444-451.
  9. Schlafer DH, Foster RA. Female genital system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier; 2016:429-430.
  10. Uzal FA, PLattner BL, Hostetter JM. Alimentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016:153-158.
  11. Woldemeskel M, Liggett A, Ilha M, Saliki J, Johnson L. Canine parvovirus-2b–associated erythema multiforme in a litter of English setter dogs. J Vet Diagn Invest. 2011;23:576-
  12. Woldemeskel MW, Saliki JT, Blas-Machado U, Whittington L. Mast cells in canine parvovirus-2-associated enteritis with crypt abscesses. Vet Pathol. 2013;50(6):989-993.
  13. Zachary JF. Mechanisms of microbial infections. In: Zachary JF, Pathologic Basis of Veterinary Disease. 6th ed. St Louis, MO: Elsevier; 2017:206-207, 216-217, 226-227.

 


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