JPC SYSTEMIC PATHOLOGY

INTEGUMENTARY SYSTEM

September 2013

I-M09

 

Signalment (JPC #1901146):  8-year-old female spayed schnauzer

HISTORY:  This dog had chronic dermatosis.

HISTOPATHOLOGIC DESCRIPTION:  Haired skin, site not specified:  Diffusely, superficial follicular infundibula and ostia are moderately expanded by eosinophilic lamellations of keratin and keratin debris (comedones). Multifocally, the epidermis is mildly hyperplastic with moderate orthokeratotic hyperkeratosis.  Often, hair shafts are missing or fragmented and follicular infundibula are lined by markedly attenuated epithelium.  Melanin pigment is present diffusely throughout all layers of the epidermis (hyperpigmentation) as well as the dermis (pigmentary incontinence), and melanin is occasionally present within the sloughed keratin debris.  Within the superficial dermis there are low numbers of mast cells and rare plasma cells.  Dermal collagen fibers are often separated by a basophilic, fibrillar to beaded material (mucinosis).  Diffusely, apocrine glands are mildly to markedly ectatic, lined by attenuated epithelium, and variably filled with a pale eosinophilic material (secretory product).

MORPHOLOGIC DIAGNOSIS:  Haired skin, site not specified:  Follicular infundibular hyperkeratosis and ectasia (comedones), diffuse, moderate, with orthokeratotic hyperkeratosis, Schnauzer, canine.

CONDITION:  Schnauzer comedo syndrome

GENERAL DISCUSSION: 

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

DIFFERENTIAL DIAGNOSIS: 

For histologic findings:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Gross TL, Ihrke PJ, Walder EJ, Affolter VK: Diseases with abnormal cornification. In: Skin Diseases of the Dog and Cat Clinical and Histopathologic Diagnosis. Ames, IA: Blackwell Science, Ltd; 2005: 181-183.
  2. Mauldin EA, Peters-Kennedy J. Integumentary system. In: In: Maxie MG Jubb, Kennedy,and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA: Elsevier Ltd. 2016:613-614.
  3. Scott DW, Miller WH, Griffin CE. Congenital and hereditary defects. In: Muller and Kirk’s Small Animal Dermatology. 7th ed. Philadelphia, PA: WB Saunders Co; 2013: 581-582.


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