JPC SYSTEMIC PATHOLOGY
REPRODUCTIVE SYSTEM
January 2019
R-N17

SIGNALMENT (JPC #4087194):  Female dog

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Ovary: Arising from the ovarian surface epithelium, filling the ovarian bursa, and compressing periovarian adipose tissue is a non-encapsulated, well demarcated, 6x3mm, densely cellular neoplasm composed of neoplastic cuboidal to columnar epithelial cells arranged in single to multilayered cords and arborizing fronds supported on a fine to moderate fibrovascular stroma.  Neoplastic cells have indistinct cell borders, a scant to moderate amount of eosinophilic fibrillar cytoplasm, a round to oval nucleus with finely stippled to clumped strands of chromatin, and 1-2 distinct nucleoli.  Anisocytosis and anisokaryosis are moderate and mitotic count average 1 per ten 400x powered objective.  Multifocally scattered throughout the neoplasm, there are few cysts that contain eosinophilic, proteinaceous material.

MORPHOLOGIC DIAGNOSIS:  Ovary: Papillary carcinoma, Shih Tzu, canine.

SYNONYMS: papillary cystadenoma / cystadenocarcinoma;

GENERAL DISCUSSION:

TYPICAL GROSS FINDINGS

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIAGNOSIS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Agnew DW, MacLachlan NJ. Tumors of the genital system. In: Meuten DJ, ed. Tumors in Domestic Animals. 5th Ames, IA: John Wiley & Sons; 2017:690-694.
  2. Banco B, Antuofermo E, Borzacchiello G, Cossu-Rocca P, Grieco V. Canine ovarian tumors: an immunohistochemical study with HBME-1 antibody. J Vet Diagn Invest. 2011 Sep;23(5):977-981.
  3. Banco B, Ferrari R, Stefanello D, Groppetti D, Pecile A, Faverzani S, Longo M, Zani DD, Ravasio G, Caniatti M, Grieco V. Ovarian embryonal carcinoma in a dog. J Comp Pathol. 2017 Nov;157(4):291-295.
  4. Foster RA. Female reproductive system and mammae. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:1162.
  5. Schlafer DH, Foster RA. Female genital system. In: Maxie MG, ed. Jubb Kennedy and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:375-377.


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