JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

September 2017

P-N02

 

Signalment (JPC #1945165):  Mouse

HISTORY:  Unknown

HISTOPATHOLOGIC DESCRIPTION:  Lung:  Expanding the pulmonary parenchyma, compressing adjacent alveoli and bronchioles and elevating the pleura is an unencapsulated, infiltrative, well demarcated, moderately cellular multilobular neoplasm.  The neoplasm is composed of cuboidal to columnar cells arranged in cords and papillary projections supported by a fine fibrovascular stroma.  Neoplastic cells have distinct cell borders with moderate amounts of a finely granular eosinophilic cytoplasm.  Nuclei are irregularly round, centrally located, and have coarsely stippled chromatin with 1-3 small basophilic nucleoli.  Mitotic figures are <1 per 10 HPF.  In the adjacent pulmonary parenchyma, alveoli are filled with macrophages and multinucleated giant macrophages which are often packed with acicular to rhomboid-shaped, intensely eosinophilic crystals; similar macrophages are occasionally admixed with neoplastic cells. Multifocally, bronchiolar epithelium is expanded by similar eosinophilic crystalline material. Alveolar septa are mildly expanded by low numbers of neutrophils and macrophages.  Multifocally, there are peribronchiolar and perivascular aggregates of lymphocytes and plasma cells (mild BALT hyperplasia).

MORPHOLOGIC DIAGNOSIS:  1. Lung: Pulmonary adenocarcinoma, mouse, murine. 2. Lung: Alveolitis, granulomatous, multifocal, moderate, with abundant intrahistiocytic and intraepithelial eosinophilic crystalline material (acidophilic macrophage pneumonia).

PREVIOUS TERMINOLOGY (abandoned):

Bronchioloalveolar adenoma:

Bronchioloalveolar carcinoma:

GENERAL DISCUSSION

Classification of primary epithelial lung tumors in domestic animals:

Benign epithelial tumors:

Papilloma, adenoma

Malignant epithelial tumors:

Pulmonary adenocarcinoma: May be single or multiple; lepidic, papillary, acinar, mixed, and other forms (micropapillary, solid, squamous)

Pulmonary carcinomas:

Acidophilic macrophage pneumonia (eosinophilic crystalline pneumonia):       

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

Pulmonary adenocarcinoma: Lepidic, papillary, and acinar patterns

Pulmonary carcinomas:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

For Cat:

 OMPARATIVE PATHOLOGY:

REFERENCES:

  1. Beck J, Miller MA, DuSold D, Ramos-Vara JA. Surfactant protein A and napsin A in the immunohistochemical characterization of canine pulmonay cacinomas: Comparison with thyroid transcription factor-1. Vet Pathol. 2017;54(5):767-774.
  2. Caswell JL, Williams KJ: Respiratory system. In: Maxie MG ed. Jubb, Kennedy, and Palmer"s Pathology of Domestic Animals. Vol 2, 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:495-498.
  3. D’Costa S, Yoon AI, Kim DY, Motsinger-Reid AA, Williams M, Kim Y. Morphologic and moleculaar analysis of 39 spontaneous feline pulmonary carcinomas. Vet Pathol. 2012;49(6):971-978.
  4. Dixon D, Herbert RA, Kissling GE, et al. Summary of chemically induced pulmonary lesions in the National Toxicology Program (NTP) toxicology and carcinogenesis studies. Toxicol Pathol. 2008; 36: 428-439.
  5. Dungworth DL, Houser B, Hahn FF, Wilson DW, Haenichen T, Harkema JR. Tumors of the Respiratory System of Domestic Animal. Volume VI., Washington DC: Armed Forces Institute of Pathology; 1999:25-33.
  6. Dungworth DL, Rittin-ghausen S, Schwartz L. Respiratory system and mesothelium. In: Mohr U ed. International Classification of Rodent Tumors; the Mouse. Hannover, Germany:Springer-Verlag; 2001: 121-122.
  7. Maronpot RR. Pathology of the Mouse. Vienna, IL: Cache River Press; 1999:306-313.
  8. Morgan DL, Nyska A, Jens Harbo S, et al. Multisite carcinogenicity and respiratory toxicity of inhaled 1-Bromopropane in rats and mice. Toxicol Pathol. 2011; 39(6):938-948.
  9. Percy DH, Barthold SW, Griffey SM. Pathology of Laboratory Rodents and Rabbits. 4rd ed. Ames, IA: Blackwell Publishing; 2016:94-95, 112-113.
  10. Wilson DW. Tumors of the respiratory tract. In: Meuten DJ ed.Tumors in Domestic Animals. 5th ed., Ames, IA: Iowa State Press; 2016: 483-488.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |