JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
October 2018
D-P18 (NP)

Signalment (JPC #287220):  Laboratory albino mouse

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Small intestine:  Multifocally expanding the lamina propria of individual villi are scattered 80-100 um diameter, oval cysticerci that lack a pseudocoelom and digestive tract and have a thin, 1-2 um wall, eosinophilic tegument, basophilic calcareous corpuscles and a single invaginated scolex armed with refractile hooklets and one to four muscular suckers.  The cysticerci are surrounded by low numbers of neutrophils and eosinophils.

MORPHOLOGIC DIAGNOSIS:  Small intestine, lamina propria:  Cysticerci, multiple, with mild multifocal neutrophilic and eosinophilic enteritis, albino mouse, rodent.

ETIOLOGIC DIAGNOSIS:  Rodentolepisial enteritis

CAUSE:  Rodentolepis nana (formerly Hymenolepis, also known as Vampirolepis nana)

GENERAL DISCUSSION:

LIFE CYCLE:

TYPICAL CLINICAL FINDINGS:

Severe infection

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Bowman DD. Georgis' Parasitology for Veterinarians. 10th ed. St. Louis, MO: Elsevier; 2014:264.
  2. Gardiner CH, Poynton SL. An Atlas of Metazoan Parasites in Animal Tissues. Washington, DC:Armed Forces Institute of Pathology;1999:52.
  3. Marty AM, Neafie RC. Hymenolepiasis. In: Meyers WM, ed. Pathology of Infectious Diseases. Vol I. Washington, DC: Armed Forces Institute of Pathology; 2000:197-212.
  4. Muehlenbachs A, Bhatnagar J, Agudelo CA, Hidron A, et al. Malignant transformation of Hymenolepis nana in a human host. N Engl J Med. 2015; 373(19):1845-1852.
  5. Percy DH, Barthold SW. Pathology of Laboratory Rodents and Rabbits. 4th Ames, IA: John Wiley & Sons, Inc.; 2016:85-86, 153, 205.


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