JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
December 2017
U-B07 (NP)

Signalment (JPC Accession # 1712745):  A 6-month-old gilt

HISTORY:  A recently bred, 6-month-old gilt exhibited hematuria for 3 or 4 days before death.  Necropsy findings included pyelonephritis, hemorrhagic ureteritis and mucohemorrhagic cystitis.

HISTOPATHOLOGIC DESCRIPTION:  Urinary bladder:  Diffusely, mucosal epithelium is thrown into papillary projections.  Multifocally, there is desquamation of the mucosal epithelium (erosion); remaining mucosal epithelial cells are mildly to moderately expanded by homogenous amphophilic and fibrillar material or variably sized clear vacuoles that peripheralize nuclei (mucinous metaplasia), or pile up to 8 cells thick (hypertrophy).  Multifocally within the mucosa there are small aggregates of neutrophils (microabcesses) and cellular and karyorrhectic debris (necrosis).  Diffusely, the lamina propria is moderately expanded by moderate numbers of lymphocytes, plasma cells, macrophages, which occasionally contain intracytoplasmic brown pigment (hemosiderin), congestion, and hemorrhage.  The muscular tunics are mildly expanded by increased fibrous connective tissue (fibrosis) and clear space with ectatic lymphatics (edema).

MORPHOLOGIC DIAGNOSIS:  Urinary bladder:  Cystitis, chronic‑active, diffuse, mild with epithelial hypertrophy, mucinous metaplasia and microabscesses, pig, breed not specified, porcine.

ETIOLOGIC DIAGNOSIS:  Bacterial cystitis

CONDITION:  Porcine cystitis and pyelonephritis

CAUSE:  Actinobaculum suis (previously Eubacterium suis, Corynebacterium suis)

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS (for Bacterial Cystitis):

COMPARATIVE PATHOLOGY:  

REFERENCES:

  1. Breshears MA, Confer AW. The urinary system. In: Zachary JF, McGavin MD, eds. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Elsevier; 2016:668.
  2. Carr J, Walton JR. Bacterial flora of the urinary tract of pigs associated with cystitis and pyelonephritis. Vet Rec. 1993; 132:575-577.
  3. Collett MG. Actinobaculum (Eubacterium) suis In: du Plessis I ed., Infectious Diseases of Livestock. Vol. 3. 2nd ed., Cape Town, South Africa:Oxford University Press; 2004:1958-1960.
  4. Taylor DJ. Miscellaneous bacterial infections. In: Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW, eds., Disease of Swine. 10th ed., Ames, IA: Blackwell Publishing; 2012:866-867.
  5. Jones TC, Hunt RD, King, NW. Veterinary Pathology. 6th ed., Baltimore, MD: Williams and Wilkins; 1997:480.
  6. Liebhold M, Wendt M, Kaup FJ, Drommer W. Clinical, and light and electron microscopical findings in sows with cystitis. Vet Rec. 1995; 137:141-144.
  7. Radostits OM, Gay CC, Hinchcliff KW, Constable PD. Veterinary Medicine: A Textbook of the Diseases of Cattle, Sheep, Pigs, Goats and Horses. 10th ed. Saint Louis, MO: Saunders Elsevier; 2010:559-560, 788, 791-793.
  8. Timoney JF, Gillespie JH, Scott FW, Barlough JE. Hagan and Bruner's Microbiology and Infectious Diseases of Domestic Animals. 8th ed., Ithaca, NY: Cornell University Press; 1988:253-254.
  9. Woldemeskel M, Drommer W, Wendt M. Microscopic and ultrastructural lesions of the ureter and renal pelvis in sows with regard to Actinobaculum suis J Vet Med A Physiol Pathol Clin Med. 2002; 49:348-352.

 

 


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