JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
September 2018
D-P07 (NP)

SIGNALMENT (JPC #2317379):  Mouse

HISTORY:  Tissue from a mouse

HISTOPATHOLOGIC DESCRIPTION:  Small intestine:  Multifocally, crypts are mildly ectatic and contain numerous eosinophilic, piriform to spindled, flagellated, 2 x 7um, protozoal trophozoites that contain two indistinct, basophilic nuclei.  Smaller numbers of similar protozoa are present in the intestinal lumen and lining villar epithelium.

MORPHOLOGIC DIAGNOSIS:  Small intestine, crypts and lumen:  Extracellular piriform flagellated protozoa, numerous, etiology consistent with Spironucleus muris, mouse, murine.

ETIOLOGIC DIAGNOSIS:  Intestinal spironucleosis

CAUSE:  Spironucleus muris

GENERAL DISCUSSION:

LIFE CYCLE:

PATHOGENESIS:

Several proposed theories for diarrhea:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

Gastrointestinal protozoa in mice:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Bailey C, Kramer J, Mejia A, et al. Systemic spironucleosis in 2 immunodeficient rhesus macaques (Macaca Mulatta). Vet Pathol. 2010; 47(3):488-494.
  2. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4rd ed. Ames, IA: John Wiley & Sons; 2016: 83-84,151,189-190.
  3. Gardiner CH, Fayer R, Dubey JP. An Atlas of Protozoan Parasites in Animal Tissues. 2nd ed. Washington, DC: Armed Forces Institute of Pathology; 1998:6-7.
  4. Sheppard BJ, Stockdale Walden HD, Kondo H. Syrian hamsters (Mesocricetus auratus) with simultaneous intestinal Giardia, Spironucleus sp., and trichomonad infections. J Vet Diag Invest. 2013; 25(6): 785-790.


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