JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

September 2017

P-M02 (NP)

 

Signalment (AFIP #1914189):  Dog, age and breed unspecified

HISTORY:  Died shortly after induction of anesthesia

HISTOPATHOLOGIC DESCRIPTION:  Multifocally  and most consistently in terminal bronchioles, extending from bronchiolar epithelium, and partially to completely occluding bronchiolar lumina, are densely cellular polyps of fibrovascular connective tissue partially lined by low cuboidal to flattened epithelium. Polyps are composed of fibroblasts, moderate amounts of collagen and low to moderate numbers of foamy macrophages, lymphocytes, and fewer plasma cells.  Low numbers of small lymphocytes surround a subset of the affected bronchioles.  Alveolar septa surrounding affected terminal bronchioles are often mildly thickened by increased numbers of lymphocytes and macrophages.  There is mild smooth muscle hyperplasia surrounding bronchioles.  Mild, diffuse, sub-pleural fibrosis is also present. 

MORPHOLOGIC DIAGNOSIS:  Lung:  Bronchiolar fibrous polyps, chronic, multifocal, moderate, (bronchiolitis obliterans), breed unspecified, canine.

SYNONYMS: bronchiolitis fibrosa obliterans, obliterative bronchiolitis, or organizing bronchiolitis

CONDITION:  Bronchiolitis obliterans, bronchiolitis fibrosa obliterans, obliterative bronchiolitis, organizing bronchiolitis

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Caswell JL, Williams KJ. Respiratory system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol. 2. 6th ed. St. Louis, MO: Elsevier Limited; 2007:504-505.
  2. Lopez A, Martinson SA. Respiratory system, mediastinum and pleurae. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St Louis, MO: Elsevier Limited; 2017:476-8.


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