EMIC PATHOLOGY

RESPIRATORY SYSTEM

August 2017

P-B11 (NP)

 

Signalment (JPC #2015661):  Ovine fetus

HISTORY:  One of two crossbred ovine fetuses that were aborted approximately 3-4 weeks prior to the expected date of parturition

HISTOPATHOLOGIC DESCRIPTION:  Lung:  There are multifocal, randomly distributed foci of necrosuppurative inflammation that affect approximately 25% of the section; these are composed of a central necrotic area of eosinophilic cellular and karyorrhectic debris and large colonies of 1 x 2 um bacilli surrounded by high numbers of viable and degenerate neutrophils, fewer macrophages and lymphocytes.  Multifocally, bacterial colonies are present within capillaries.  Diffusely, the remaining alveolar spaces, septa, vasculature, and bronchioles contain scattered inflammatory cells, eosinophilic, fibrillar material (fibrin), few erythrocytes (hemorrhage), necrotic cellular debris, and rarely globular yellow material (meconium).  There are widely dilated lymphatics and amorphic, homogenous, eosinophilic material (edema) that expands the perivascular space.  Diffusely, there is atelectasis and congestion.

MORPHOLOGIC DIAGNOSIS:  Lung:  Pneumonia, necrosuppurative, subacute, severe, with meconium and numerous large bacterial colonies, crossbred sheep, ovine

ETIOLOGIC DIAGNOSIS:  Pulmonary yersiniosis

CAUSE:  Yersinia pseudotuberculosis

GENERAL DISCUSSION: 

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

Bacteria that appear histologically as large colonies:

COMPARATIVE PATHOLOGY: 

REFERENCES:

  1. Cheville NF. Ultrastructural Pathology:  An Introduction to Interpretation. Ames, IA: Iowa State University Press; 1994:656-657. 
  2. Childs-Sanford SE, Kollias GV, Abou-Madi N, McDonough PL, Garner MM, Mohammed HO. Yersinia pseudotuberculosis in a closed colony of Egyptian fruit bats (Rousettus aegyptiacus). J Zoo Wildl Med. 2009;40(1):8-14.
  3. Galosi L, Farneti S, et al. Yersinia pseudotuberculosis, serogroup O:1A, infection in two Amazon parrots (Amazona aestiva and Amazona oratrix) with hepatic hemosiderosis. J Zoo Wildl Med. 2015 Sep;46(3):588-91.
  4. Gaydos JK, Zabek E, Raverty S. Yersinia Pseudotuberculosis septicemia in a beaver from Washington State. J Wildl Dis. 2009; 45(4):1182-6.
  5. Giannitti F, Barr BC, et al. Yersinia pseudotuberculosis infections in goats and other animals diagnosed at the California Animal Health and Food Safety Laboratory System: 1990-2012. J Vet Diagn Invest. 2014 Jan;26(1):88-95.
  6. Giles C, Boerlin P. Horizontally transferred genetic elements and their role in pathogenesis of bacterial disease. Vet Pathol. 2014; 51(2):328-340.
  7. Gyuranecz M, Szeredi L, Makrai L, Fodor L, M´esza´ros AR, et al. Tularemia of European brown hare (Lepus europaeus): a pathological, histopathological, and immunohistochemical study. Vet Pathol.  2010; 47(5):958-963.
  8. Nakamura S, Hayashidani H, Okabe N, Une Y. Aberrant forms of Yersinia pseudotuberculosis as spheroplasts and filaments in yersiniosis in squirrel monkeys.  Vet Pathol. 2014; 51(2):1-4.
  9. Nakamura S, Hayashidani H, et al. Yersiniosis due to infection by Yersinia pseudotuberculosis 4b in captive meerkats (Suricata suricatta) in Japan. J Vet Diagn Invest. 2015 Sep;27(5):641-4.
  10. Percy DH, Barthold SW. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: Blackwell Publishing; 2016:288.
  11. Stoute ST, Cooper GL, et al. Yersinia pseudotuberculosis in Eurasian Collared Doves (Streptopelia decaocto) and Retrospective Study of Avian Yersiniosis at the California Animal Health and Food Safety Laboratory System (1990-2015). Avian Dis. 2016 Mar;60(1):82-86.
  12. Valli VEO, Kiupel M, Bienzle D. Hematopoietic System. In: Maxie MG, ed. Jubb, Kennedy, and Palmer's Pathology of Domestic Animals.  Vol 3. 6th ed. St. Louis, MO: Elsevier; 2016:209-210.
  13. Uzal FA, Plattner BL, Hostetter JM. Alimentary system.  In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals.  Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016:176-177.
  14. Wessels, ME, Payne JH, Bannerman RP. Oculoglandular syndrome caused by Yersinia pseudotuberculosis in a dairy goat. J Comp Pathol. 2009; 141(2-3):190-4.


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