JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
Novemer 2018
D-V19

Signalment (JPC #1154150):  Young dog

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Liver:  Diffusely affecting greater than 95% of the liver is centrilobular to midzonal (submassive) lytic necrosis characterized by disruption of hepatic cord architecture and loss of hepatocytes with replacement by abundant fibrin, hemorrhage, and necrotic debris, admixed with low numbers of neutrophils and lymphocytes.  Hepatocytes at the periphery of affected areas often are degenerate, characterized by cell swelling with vacuolated cytoplasm, or necrotic, characterized by shrunken cells, with hypereosinophilic cytoplasm and faded or pyknotic nuclei, and often containing basophilic, 4-8 um diameter, round to oval intranuclear basophilic viral inclusion bodies that are surrounded by a clear halo and marginated chromatin.  Similar intranuclear inclusion bodies are frequently present in Kupffer cells.  Multifocally endothelium within portal vasculature is hypertrophied and rarely contains the previously described intranuclear inclusions.  Multifocally within surrounding hepatic sinusoids are low numbers of neutrophils and lymphocytes. 

MORPHOLOGIC DIAGNOSIS:  Liver:  Hepatitis, necrotizing, centrilobular to midzonal (submassive), acute, diffuse, severe, with hemorrhage and basophilic intranuclear viral inclusion bodies, breed unspecified, canine.

ETIOLOGIC DIAGNOSIS:  Adenoviral hepatitis

CAUSE:  Canine adenovirus type 1 (CAV1)

CONDITION:  Infectious canine hepatitis (ICH)

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

Five genera:

REFERENCES:

  1. Cianciolo RE, Mohr FC. Urinary System. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol. 2. 6th ed. St. Louis MO: Elsevier Ltd; 2016:410.
  2. Cullen JM, Stalker MJ. Liver and biliary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol. 2. 6th ed. St. Louis MO: Elsevier Ltd; 2016:310-312.
  3. Fitzgerald SD, Hess M, Smyth JA, Pierson FW, Reed WM, Jack SW. Adenovirus infections. In: Swayne DE, ed. Diseases of Poultry. 13th ed. Ames, IA: John Wiley & Sons, Inc; 2013: 289-331.
  4. Greene CE. Infectious canine hepatitis and canine acidophil cell hepatitis. In: Greene CE, ed. Infectious Diseases of the Dog and Cat. 4th ed. St Louis, MO: Saunders Elsevier; 2012:42-47.
  5. Wachtman L, Mansfield K. Viral Diseases of Nonhuman Primates. In: Abee, ed. Nonhuman Primates in Biomedical Research: Diseases. Volume 2. San Diego, CA: Elsevier Inc; 2012:27-30.
  6. Wilcock, BP, Njaa BL. Special Senses. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol. 1. 6th ed. St. Louis MO: Elsevier Ltd; 2016:452-453.
  7. Zachary JF. Mechanisms of microbial infections. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:207.


Click the slide to view.



Click on image for diagnostic series.



Back | Home | Contact Us | Links | Help |