February 2018

Signalment (JPC #3106379 / WSC 08-09 conference 14; case 2):  Juvenile, female, Mahogany, (Mustela vison), mink

HISTORY:  None provided

HISTOPATHOLOGICIC DESCRIPTION:  Kidney:  Diffusely, glomerular capillary lumina are often indistinct, and glomeruli exhibit one or more of the following changes:  increased cellularity of the mesangium, increased eosinophilic hyaline material within the mesangium and/or glomerular basement membrane (hyalinosis or sclerosis), segmental to global replacement by eosinophilic cellular and karyorrhectic debris (necrosis) admixed with occasional hemorrhage and rare neutrophils, or segmental to global replacement of glomerular tuft components by mesangial matrix, sclerotic collagen and/or fibrous connective tissue (sclerosis).  Multifocally, the parietal epithelium of Bowman’s capsule is hypertrophied.  Tubular epithelium is often either pale, swollen, and vacuolated (degenerative), shrunken and hypereosinophilic (necrotic), or rarely has increased basophilia with plump, vesiculate nuclei (regenerative).  The interstitium contains multifocal infiltrates of abundant lymphocytes and plasma cells that occasionally replace tubules.  Multifocally, the tunica media of small to medium-sized arterioles is thickened by eosinophilic hyaline material admixed with hemorrhage and edema (fibrinoid vasculitis), and are transmigrated and surrounded by variable numbers of lymphocytes and plasma cells.  In the tunica intima the endothelium is hypertrophied or effaced and replaced by fibrin and debris.  Multifocally there are ectatic lymphatics and increased clear space (edema). 

Urinary bladder:  Diffusely, arterial walls are replaced with a hypereosinophilic hyaline material with multifocal cellular debris and are surrounded by abundant lymphocytes, plasma cells, few macrophages, eosinophils, and fibrosis.

MORPHOLOGIC DIAGNOSIS:  Kidney:  Glomerulonephritis, membranoproliferative (presumptive), diffuse, moderate, with multifocal fibrinonecrotizing arteriolitis, lymphoplasmacytic interstitial nephritis, and tubular degeneration and necrosis, mink (Mustela vison), mustelid.

Urinary bladder: Arteritis, fibrinonecrotizing, diffuse, severe, with perivascular lymphoplasmacytic cystitis.

ETIOLOGIC DIAGNOSIS:  Parvoviral glomerulonephritis and arteritis.

CAUSE:  Aleutian mink disease virus (Amdovirus, ADV, AMDV)

SYNONYMS:  Aleutian mink disease, mink plasmacytosis










ADV in other species:

Other parvoviruses:  Parvovirus in many species targets crypt epithelium of the small intestine, resulting in intestinal disease, but rodent parvoviruses do not target intestinal epithelium.


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