JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
February 2018
U-V05

Signalment (JPC #3106379 / WSC 08-09 conference 14; case 2):  Juvenile, female, Mahogany, (Mustela vison), mink

HISTORY:  None provided

HISTOPATHOLOGICIC DESCRIPTION:  Kidney:  Diffusely, glomerular capillary lumina are often indistinct, and glomeruli exhibit one or more of the following changes:  increased cellularity of the mesangium, increased eosinophilic hyaline material within the mesangium and/or glomerular basement membrane (hyalinosis or sclerosis), segmental to global replacement by eosinophilic cellular and karyorrhectic debris (necrosis) admixed with occasional hemorrhage and rare neutrophils, or segmental to global replacement of glomerular tuft components by mesangial matrix, sclerotic collagen and/or fibrous connective tissue (sclerosis).  Multifocally, the parietal epithelium of Bowman’s capsule is hypertrophied.  Tubular epithelium is often either pale, swollen, and vacuolated (degenerative), shrunken and hypereosinophilic (necrotic), or rarely has increased basophilia with plump, vesiculate nuclei (regenerative).  The interstitium contains multifocal infiltrates of abundant lymphocytes and plasma cells that occasionally replace tubules.  Multifocally, the tunica media of small to medium-sized arterioles is thickened by eosinophilic hyaline material admixed with hemorrhage and edema (fibrinoid vasculitis), and are transmigrated and surrounded by variable numbers of lymphocytes and plasma cells.  In the tunica intima the endothelium is hypertrophied or effaced and replaced by fibrin and debris.  Multifocally there are ectatic lymphatics and increased clear space (edema). 

Urinary bladder:  Diffusely, arterial walls are replaced with a hypereosinophilic hyaline material with multifocal cellular debris and are surrounded by abundant lymphocytes, plasma cells, few macrophages, eosinophils, and fibrosis.

MORPHOLOGIC DIAGNOSIS:  Kidney:  Glomerulonephritis, membranoproliferative (presumptive), diffuse, moderate, with multifocal fibrinonecrotizing arteriolitis, lymphoplasmacytic interstitial nephritis, and tubular degeneration and necrosis, mink (Mustela vison), mustelid.

Urinary bladder: Arteritis, fibrinonecrotizing, diffuse, severe, with perivascular lymphoplasmacytic cystitis.

ETIOLOGIC DIAGNOSIS:  Parvoviral glomerulonephritis and arteritis.

CAUSE:  Aleutian mink disease virus (Amdovirus, ADV, AMDV)

SYNONYMS:  Aleutian mink disease, mink plasmacytosis

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS: 

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY: 

ADV in other species:

Other parvoviruses:  Parvovirus in many species targets crypt epithelium of the small intestine, resulting in intestinal disease, but rodent parvoviruses do not target intestinal epithelium.

REFERENCES: 

  1. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents and Rabbits. 4th ed. Ames, IA: Blackwell Publishing; 2016: 17-19, 122-124, 175-176, 196, 259
  2. Farid AH, Hussain I, Arju I. Detection of Aleutian mink disease virus DNA and antiviral antibodies in American mink (Neovison vison) 10 days postinoculation.  J Vet Diagn Invest. 2015:27(3):287-294.
  3. Ford J, McEndaffer L, Renshaw R, Molesan A, Kelly K. Parvovirus infection is associated with myocarditis and myocardial fibrosis in young dogs.  Pathol. 2017;54(6): 964-971.
  4. Kollias GV, Fernandez-Moran J.   In: Miller RE, Fowler ME.  Fowler’s zoo and wild animal medicine. Vol. 8.  St. Louis, MO: Elsevier; 2015: 484.
  5. Kiupel M, Perpinan D. Viral diseases of ferrets.  In: Fox JG, Marini RP. Biology and diseases of the ferret.  3rd ed.  Ames, IA: Wiley; 2014: 461-467.
  6. LaDouceur EEB, Anderson M, Ritchie BW, Ciembor P, Rimoldi G, Piazza M, Pesti D, Clifford DL, Gianniti F. Aleutian disease: an emerging disease in free-ranging striped skunks (Mephitis mephitis) from California.  Pathol. 2015;52(6):1250-1253.
  7. Li L, Pesavento PA, Woods L, et al. Novel amdovirus in gray foxes. Emerg Infect Dis. 2011:17(10):1876-8.
  8. MacLachlan NJ, Dubovi EJ, Eds. Fenner’s Veterinary Virology. 5th ed. San Diego, CA: Academic Press.  2017;245-257.
  9. Nituch LA, Bowman J, Wilson PJ, Schulte-Hostedde AI. Aleutian mink disease virus in striped skunks (Mephitis mephitis): evidence for cross-species spillover.  Wildl. Dis.2015;51(2):389-400.
  10. Quesenberry KE, Carpenter JW. Ferrets, Rabbits, and Rodents Clinical Medicine and Surgery. 3rd ed. St. Louis, MO: Elsevier; 2012: 48, 71-73, 135-136.
  11. Snyder PW. Diseases of immunity. In: Zachary JD, ed., Pathologic Basis of Veterinary Disease.6th ed. St. Louis, MO: Elsevier; 2017: 266.
  12. Uzal FA, Plattner BL, Hostetter JM. Alimentary system.  In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals.  Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016:153-158.
  13. Wilson DJ, Baldwin TJ, Whitehouse CH, Hullinger G. Causes of mortality in farmed mink in the intermountain west, North America.  J Vet Diagn Invest. 2015:27(4):470-475.

 

 


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