JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
December 2017
U-M02 (NP)

Signalment (JPC# 86-950):  A 4-month-old calf

HISTORY:  Tissue from a calf euthanized because of necrotizing glossitis and abscessation of the mandible

HISTOPATHOLOGIC DESCRIPTION:  Kidney, periodic acid-Schiff stain (PAS) stain:  Diffusely, cortical tubular epithelial cells contain single to multiple, irregularly round, intracytoplasmic, variably PAS-positive (bright pink to red) bodies that measure up to 15um in diameter.  Multifocally, medullary tubular epithelial cells occasionally contain similar intracytoplasmic, PAS-positive material.  There is mild diffuse subcapsular tubular ectasia.  Focally, the interstitium is minimally expanded by few lymphocytes and plasma cells.

MORPHOLOGIC DIAGNOSIS: Kidney, tubular epithelium:  Intracytoplasmic PAS-positive bodies, diffuse, moderate, breed unspecified, bovine.

ETIOLOGIC DIAGNOSIS: Hereditary renal tubule hypergranulation

CAUSE:  Hereditary

CONDITION: Chédiak-Higashi Syndrome (CHS)

GENERAL DISCUSSION:

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY: 

REFERENCES: 

  1. Boes KM, Durham AC. Bone marrow, blood cells, and the lymphoid/lymphatic system. In: Zachary JF, ed. Pathological Basis of Veterinary Disease. 6th ed. Philadelphia, PA: Mosby Elsevier Inc.; 2017:746.
  2. Mauldin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:556.
  3. Mosier DA. Vascular disorders and thrombosis. In: Zachary JF, ed. Pathological Basis of Veterinary Disease. 6th ed. Philadelphia, PA: Mosby Elsevier Inc.; 2017:60.
  4. Snyder PW. Diseases of immunity. In: Zachary JF, ed. Pathological Basis of Veterinary Disease. 6th ed. Philadelphia, PA: Mosby Elsevier Inc.; 2017:285.
  5. Tizard IR. Veterinary immunology, an introduction. 8th ed. St. Louis, MO: Saunders Elsevier; 2009:449.
  6. Valli VEO, Kiupel M, Bienzle D. Hematopoietic system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:110,259.


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