October 2018
D-T14 (NP)

Signalment (JPC #2548607):  3-month-old mixed breed beef heifer

HISTORY:  This heifer was one of several calves and cows that were acutely ill.  Several died in the last four months.  This calf died enroute to the laboratory.  A bottle of monosodium methanearsonate herbicide with a pinhole leak had been dripping into a meal supplement in a storage shed.

HISTOPATHOLOGIC DESCRIPTION:  Rumen:  Diffusely there is a lack of normal ruminal papillar architecture with blunting, collapse and loss of papillae.  The mucosal epithelium is eroded, ulcerated, and multifocally separated from the underlying lamina propria and replaced by eosinophilic cellular and karyorrhectic debris (necrosis), keratin debris, eosinophilic fibrillar fibrin, hemorrhage, edema, numerous viable and degenerate neutrophils and fewer lymphocytes and plasma cells, and few small colonies of coccobacilli.  Multifocally within the lamina propria, most severely underlying areas of ulceration, there is necrotic debris, viable and degenerate neutrophils, edema and fibrin.  Edema and neutrophils extend transmurally through all layers of the rumen to the serosa.. 

MORPHOLOGIC DIAGNOSIS:  Rumen:  Rumenitis, necrohemorrhagic and neutrophilic, acute, diffuse, severe, with transmural congestion and edema, mixed breed, bovine.

ETIOLOGIC DIAGNOSIS:  Rumenal arsenic toxicosis

CAUSE:  Organic arsenic (trivalent)







DIFFERENTIAL DIAGNOSIS (for clinical signs):



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