JPC SYSTEMIC PATHOLOGY
REPRODUCTIVE SYSTEM
January 2019
R-V02

Signalment (JPC# 1367008):  A bull

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Prepuce:  Multifocally the epidermis is eroded or ulcerated and the subjacent dermis is infiltrated by numerous viable and degenerate neutrophils, fewer lymphocytes, plasma cells, and macrophages admixed with eosinophilic cellular and karyhorrectic debris, fibrin, and edema. Immediately adjacent to the ulcers, keratinocytes within the stratum spinosum are separated by increased clear space with prominent intercellular bridges (spongiosis), and are swollen up to 2 times normal size with pale, eosinophilic cytoplasm (intracellular edema).  Occasionally nuclei within the epidermis contain irregular, round to oval, eosinophilic to amphophilic, 5-7 um diameter viral inclusion bodies, which either fill the nucleus and/or marginate the chromatin and are rimmed by a clear halo.  Diffusely within the dermis, immediately subjacent to the dermoepidermal junction there are high numbers of lymphocytes and plasma cells. Multifocally away from the ulcers, there is neutrophilic exocytosis through the epidermis. Dermal blood vessels are multifocally lined by plump, reactive endothelial cells and contain moderate numbers of transmigrating neutrophils, and dermal collagen is mildly separated by clear space (edema).

MORPHOLOGIC DIAGNOSIS:  Prepuce:  Posthitis, ulcerative, subacute, multifocal, moderate, with epithelial eosinophilic intranuclear viral inclusion bodies, breed unspecified, bovine.

ETIOLOGY:  Bovine herpesvirus-1

ETIOLOGIC DIAGNOSIS:  Herpesviral posthitis

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSES:  

COMPARATIVE PATHOLOGY:  

REFERENCES:

  1. Bellehumeur C, Lair S, Romero CH, Provost C, Nielsen O and Gagnon CA. Identification of a novel herpesvirus associated with a penile proliferative lesion in a beluga (Delphinapterus leucas). J Wildl Dis. 2015;51(1):244-249
  2. Foster RA. Male genital system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 3. 6th St. Louis, MO: Elsevier; 2016:506-507.
  3. Laguardia-Nascimento M, Sales EB, et al. Detection of multiple viral infections in cattle and buffalo with suspected vesicular disease in Brazil. J Vet Diagn Invest. 2016;28(4):377-381.
  4. Schalfer DH, Foster RA. Female genital system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier; 2016:433-434.


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