April 2018
H-M04 (NP)

Signalment (JPC #A29):  5-week-old Holstein calf

HISTORY:  This calf was born with a leukocyte count of 17,400/ul (65% PMN).  At 2 days of age, 23,200/ul (78% PMN); at 14 days of age, 36,600/ul (87% PMN); at 22 days of age, 54,200/ul (93% PMN); at 25 days of age, the calf had a fever of 106 degrees Fahrenheit (41 degrees Celsius), a leukocyte count of 65,000/ul and was unresponsive to antipyretic therapy.  At 35 days of age, the calf died during the night.

HISTOPATHOLOGIC DESCRIPTION:  1.  Spleen:  Diffusely the white pulp is decreased and red pulp is markedly expanded by numerous mature neutrophils, fewer plasma cells, lymphocytes, and macrophages admixed with abundant eosinophilic, beaded material (fibrin) and eosinophilic homogeneous fluid (edema).  Multifocally there are circumscribed areas of necrosis characterized by a central area with loss of architecture and replacement with abundant eosinophilic cellular and karyorrhectic debris (necrosis) surrounded by many degenerate and viable neutrophils admixed with abundant fibrin and edema.  The splenic capsule is thickened by fibrin and low numbers of neutrophils, lymphocytes, and macrophages.  Capsular lymphatics are ectatic (edema).

  1. Bone marrow: The bone marrow is mildly hypercellular and precursors of all blood cell lines are represented.  Over 50% of the cells present are progenitor/proliferating cells of the myeloid series.  The myeloid to erythroid (M:E) ratio is approximately 3:1.

MORPHOLOGIC DIAGNOSIS:  1.  Spleen:  Splenitis, neutrophilic and necrotizing, diffuse, moderate with marked lymphoid depletion, Holstein, bovine.

  1. Bone marrow: Myeloid hyperplasia with increased progenitor cells, diffuse, moderate.

CAUSE:  CD11/CD18 glycoprotein deficiency, autosomal recessive inheritance


Bovine leukocyte adhesion deficiency (BLAD)









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