JPC SYSTEMIC PATHOLOGY

RESPIRATORY SYSTEM

August 2017

P-B07

 

Signalment (JPC# 1361378):   A Mangabey (Cercocebus sp.)

HISTORY:  This monkey died shortly after arrival from the supplier.

HISTOPATHOLOGICAL DESCRIPTION:  Lung:  Diffusely filling alveolar and bronchiolar lumina, obscuring (and occasionally effacing) bronchial/ bronchiolar walls and alveolar septa there is abundant hemorrhage, fibrin, wispy heterogeneous eosinophilic material interpreted as karyorrhectic (necrotic) debris, edema fluid, and moderate numbers of degenerate and non-degenerate neutrophils, lymphocytes, and plasma cells.  Multifocally, remaining alveolar septa are moderately expanded with edema, fibrin, neutrophils, and occasionally lymphocytes and plasma cells.  Alveoli are multifocally dilated with discontinuous septa (alveolar emphysema).  Bronchiolar epithelial cells are cuboidal to attenuated, with absence of cilia, or denuded.  There is multifocal expansion of peribronchiolar and perivascular connective tissue up to 5x normal by hemorrhage, fibrin, and edema.  The endothelium and tunica media of multiple pulmonary vessels are disrupted and expanded by low numbers of nondegenerate and degenerate neutrophils and necrotic debris (necrotizing vasculitis), with abundant perivascular hemorrhage, fibrin and edema.

MORPHOLOGIC DIAGNOSIS:  Lung:  Bronchopneumonia, fibrinohemorrhagic, and necrosuppurative, acute, diffuse, severe, Mangabey (Cercocebus sp.), nonhuman primate.

ETIOLOGIC DIAGNOSIS:  Streptococcal pneumonia

CAUSE:  Streptococcus pneumoniae

ETIOLOGY SYNONYMSDiplococcus pneumoniae, Pneumococcus pneumoniae

GENERAL DISCUSSION:

PATHOGENESIS:  

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:
Pneumonia:

Meningitis in nonhuman primates:

COMPARATIVE PATHOLOGY:

References: 

  1. Abee CR, Mansfeld K, Tardiff S, Morris T. Nonhuman Primates in Biomedical Research, Volume 2: Diseases. San Diego, CA: Academic Press; 2012:107-109,452-453.
  2. Barthold SW, Griffey SM, Percy DH. Pathology of Laboratory Rodents & Rabbits. 4th ed. Ames, IA: Blackwell Publishing Ltd; 2016:144-145,186,230.
  3. Greene CE, Prescott JF. Streptococcal infections. In: Greene CE, ed. Infectious Diseases of the Dog and Cat. 4th ed. St Louis, MO: W.B. Elsevier Saunders; 2012: 327-328.
  4. Kumar V, Abbas AK, Aster JC. Infectious disease. In: Kumar V, Abbas AK, Aster JC. eds. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2014:364-365.
  5. Lopez A, Martinson SA. Respiratory system, mediastinum, and pleurae, In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2016:518.
  6. Magden ER, Mansfield KG, Simmons JH. Nonhuman primates. In: Fox JG, Anderson LC, Otto G, Pritchett-Corning KR, Whary MT, Fox JG, eds. Laboratory Animal Medicine, 3rd ed. San Diego, CA: Academic Press; 2015:851.
  7. Unwin S, Chatterton J, Chantrey J. Management of severe respiratory tract disease caused by human respiratory syncytial virus and streptococcus pneumonia in captive chimpanzees (Pan troglodytes). J Zoo Wildl Med 2013;44(1):105-115.


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