JPC SYSTEMIC PATHOLOGY
SPECIAL SENSES SYSTEM
APRIL 2018
S-M05

Signalment:  Tissue from an English setter.

HISTORY:  This 9-week-old female English setter dog had posterior capsular pigmentation, retinal detachment, and neovascularization; the eye was enucleated.

HISTOPATHOLOGIC DESCRIPTION:  Eye: Diffusely, the retina is disorganized, folded, and seperated from the underlying retinal pigment epithelium (RPE).  Multifocally, there is loss of the normal retinal architecture, characterized by variation in thickness of the outer and inner nuclear layers, extensive loss and thinning of the outer plexiform layer, and multifocal coalescence of the two nuclear layers.  The outer nuclear layer multifocally forms rosettes composed of neuroblastic cells which surround a central clear space and contain eosinophilic fibrils (rods and cones).  Ganglion cells are multifocally clustered in areas of retinal folding and there is vacuolation (axonal degeneration and/or spongiosis) in the nerve fiber layer.  Diffusely, cells of the RPE are hypertrophied and rounded (tombstoning).  There is a focal area of fibrous metaplasia on the posterior aspect of the lens. Focally, the margin of the iris is curved outward toward the anterior chamber (ectropion uveae).

MORPHOLOGIC DIAGNOSIS:  Eye, retina:  Dysplasia, diffuse, severe with multifocal retinal folds - rosettes, and thinning of outer plexiform layer, with retinal detachment, English setter, canine.

CONDITION:  Retinal dysplasia

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Bauer BS, Forsyth GW, Sandmeyer LS, et al. Relative quantification of white blood cell mitochondrial DNA and assessment of mitochondria by use of transmission electron microscopy in English Springer Spaniels with and without retinal dysplasia. Am J Vet Res. 2010; 71(4): 454-459.
  2. Chambers JK, Nakamori T, Kishimoto TE, et al. Lachrymal gland basal cell adenocarcinoma in a ferret (Mustela putorius furo). J Comp Pathol. 2016; 155 (2-3): 259-262
  3. Dubielzig RR, Ketring KL, McLellan GJ, et al. eds. Veterinary Ocular Pathology: A Comparative Review. St. Louis, MO: Elsevier Saunders; 2010: 33, 39-42.
  4. Gelatt KN, Plummer CE. Color Atlas of Veterinary Ophthalmology. 2nd Ames, IA: Wiley Blackwell; 2017:219-220, 277.
  5. Grahn BH. Inherited retinal dysplasia and persistent hyperplastic primary vitreous in Miniature Schnauzer dogs. Vet Ophthalmol. 2004; 7:151-158.
  6. Labelle P. The eye. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Elsevier; 2017: 1307-1308.
  7. Ofri R. Retina. In: Maggs DJ, Miller PE, Orfi R, eds. Slatter’s Fundamentals of Veterinary Ophthalmology. 4th ed. St. Louis, MO: Elsevier Saunders; 2008:304-307.
  8. Uchida K, Kunieda T, Abbasi AR, et al. Congenital multiple ocular defects with falciform retinal folds among Japanese black cattle. Vet Pathol. 2006;43(6):1017-1021
  9. Wilcock BP, Njaa BL. Special senses. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th St. Louis, MO: Elsevier; 2016:419-420, 469-470.
  10. Williams DL, Simpson VR, Flindall A. Retinal dysplasia in wild otters (Lutra lutra). Vet Rec. 2004; 155: 52-56.


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