APRIL 2018

Signalment:  Tissue from an English setter.

HISTORY:  This 9-week-old female English setter dog had posterior capsular pigmentation, retinal detachment, and neovascularization; the eye was enucleated.

HISTOPATHOLOGIC DESCRIPTION:  Eye: Diffusely, the retina is disorganized, folded, and seperated from the underlying retinal pigment epithelium (RPE).  Multifocally, there is loss of the normal retinal architecture, characterized by variation in thickness of the outer and inner nuclear layers, extensive loss and thinning of the outer plexiform layer, and multifocal coalescence of the two nuclear layers.  The outer nuclear layer multifocally forms rosettes composed of neuroblastic cells which surround a central clear space and contain eosinophilic fibrils (rods and cones).  Ganglion cells are multifocally clustered in areas of retinal folding and there is vacuolation (axonal degeneration and/or spongiosis) in the nerve fiber layer.  Diffusely, cells of the RPE are hypertrophied and rounded (tombstoning).  There is a focal area of fibrous metaplasia on the posterior aspect of the lens. Focally, the margin of the iris is curved outward toward the anterior chamber (ectropion uveae).

MORPHOLOGIC DIAGNOSIS:  Eye, retina:  Dysplasia, diffuse, severe with multifocal retinal folds - rosettes, and thinning of outer plexiform layer, with retinal detachment, English setter, canine.

CONDITION:  Retinal dysplasia








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