JPC SYSTEMIC PATHOLOGY
HEMOLYMPHATICS SYSTEM
April 2018
H-P02 (NP)

Signalment (POLA File):  Dog, age, breed and sex unspecified

HISTORY:  This dog was anemic

HISTOPATHOLOGIC DESCRIPTION:  Cytologic specimen, peripheral blood smear: Approximately 30% of the erythrocytes contain pale basophilic intracellular protozoa with a single, acidophilic, eccentric 1 um diameter nucleus.  The protozoa have varying morphology characterized by either 3-4 um in diameter single, round, ring stages (trophozoites); 4-5 x 2-3 um pairs of pyriform bodies (merozoites/”piroplasms”) and fewer tetrads of cruciform bodies.  There is also mild polychromasia, poikilocytosis, anisocytosis, spherocytosis, thrombocytopenia, and multifocal agglutination of parasitized erythrocytes.

Differential white cell count:  Segmented neutrophils – 81%, Bands – 3%, Monocytes – 2%, Lymphocytes – 14%

MORPHOLOGIC DIAGNOSIS:  Cytologic specimen, peripheral blood smear: Regenerative anemia, mild with thrombocytopenia and many intraerythrocytic protozoa, etiology consistent with Babesia spp., breed unspecified, canine.

CAUSE:  Babesia canis

CONDITION:  Babesiosis, piroplasmosis

GENERAL DISCUSSION: 

PATHOGENESIS: 

 LIFE CYCLE:

TYPICAL CLINICAL FINDINGS:

Clinical Pathology:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY

Species names in bold type are present in the United States:

 References:

  1. Boes KM, Durham AC. Bone marrow, blood cells, and lymphatic system. In: Zachary JF ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Saunders Elsevier; 2017:748.
  2. Kongklieng A, Intapan PM, et al. Detection of Babesia canis vogeli and Hepatozoon canis in canine blood by a single-tube real-time fluorescence resonance energy transfer polymerase chain reaction assay and melting curve analysis. J Vet Diagn Invest. 2015; 27(2):191-195.
  3. Mauldin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:665.
  4. Valli VEO, Kiupel M, et al. Hematopoietic system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:117-120.
  5. Zabolotzky SM, Walker DB. Peripheral blood smears. In: Valenciano AC, Cowell RL, eds. Diagnostic Cytology and Hematology of the Dog and Cat. 4th ed. St. Louis, MO: Elsevier; 2014:475.


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