JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
January 2018
U-M22 (NP)

Signalment (JPC 1629346): Dog

HISTORY: Slide U-M22a: Incidental histologic finding in a dog

HISTOPATHOLOGIC DESCRIPTION: Kidney: Multifocally within the cortex, proximal tubular epithelial cells contain single brightly eosinophilic, acicular, 5 by 10-15 um intranuclear inclusions which are occasionally elongate and distend the nuclei. Focally, there is distortion of the architecture a glomerular tuft by a closely packed aggregate of polygonal foam cells with vacuolated, pale eosinophilic cytoplasm (glomerular lipidosis). Multifocally, proximal tubular epithelial cells and less often glomerular podocytes contain brown to yellow globular intracytoplasmic pigment.  

Liver: Occasional hepatocytes contain intranuclear inclusions as previously described.

MORPHOLOGIC DIAGNOSIS: 1. Kidney, proximal tubule epithelium:  Intranuclear inclusions, multiple, with minimal glomerular lipidosis, breed not specified, canine

  1. Liver, hepatocytes: Intranuclear inclusions, few

Signalment (JPC Accession #850256-4A): Rhesus monkey

HISTORY: Slide U-M22b: Incidental histologic finding in a rhesus monkey

HISTOPATHOLOGIC DESCRIPTION: Kidney: Multifocally, pelvic urothelial cells contain 1 to 2 round to oval, up to 10 um diameter, brightly eosinophilic, granular, intracytoplasmic inclusion bodies.

MORPHOLOGIC DIAGNOSIS: Kidney, pelvic urothelium: Intracytoplasmic inclusions, few, rhesus macaque, nonhuman primate

ETIOLOGIC DIAGNOSIS: Nonspecific renal and hepatic inclusions.

CAUSE: Unknown

GENERAL DISCUSSION:

PATHOGENESIS: Unknown

TYPICAL CLINICAL FINDINGS: None

TYPICAL GROSS FINDINGS: None

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Baze WB, Steinbach TJ, Fleetwood ML, Blanchard TW, Barnhart KF, McArthur MJ. Karyomegaly and intranuclear inclusions in the renal tubules of sentinel ICR mice (mus musculus). Comp Med 2006;56(5):435-8.
  2. Cianciolo RE, Mohr FC. Urinary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. 6th ed. St. Louis, MO: Elsevier; 2016:430.
  3. Cullen JM, Stalker MJ. Liver and biliary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer's Pathology of Domestic Animals. 6th ed. Vol 2. Philadelphia, PA: Elsevier Saunders;2016:270.

 

 


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