JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
January 2018
U-T17

Signalment:  7-month-old female Yucatan minipig

HISTORY:   Received a lethal dose of a toxic substance and died in severe respiratory distress 24 hours later

HISTOPATHOLOGIC DESCRIPTION:  Kidney:  Diffusely, glomeruli have one or more of the following changes:  marked capillary congestion or fibrin thrombi; necrosis and mesangiolysis, characterized by pyknotic or karyorrhectic endothelial or mesangial nuclei; proteinosis, characterized by uriniferous spaces filled with homogeneous eosinophilic material; and hypertrophic parietal epithelium.  Tubular epithelial cells multifocally have one or more of the following changes: degeneration, characterized by swollen, vacuolated cytoplasm with pale nuclei; hyaline droplets; or necrosis, characterized by shrunken hypereosinophilic cells with pyknosis.  Multifocally tubules are mildly ectatic with proteinosis, characterized by tubular lumina that are variably filled with eosinophilic material. Interstitial capillaries are diffusely dilated by congestion and multifocally by fibrin thrombi admixed with necrotic debris.  There is occasional deposition of deeply basophilic mineral within glomerular and interstitial capillary basement membranes. 

MORPHOLOGIC DIAGNOSIS:  Kidney, glomeruli and interstitial capillaries:  Fibrin thrombi, numerous, diffuse, with glomerular and tubular degeneration, necrosis and proteinosis, Yucatan minipig (Sus scrofa), porcine.

ETIOLOGIC DIAGNOSIS:  Renal ricin toxicosis

CAUSE:  Ricin

GENERAL DISCUSSION: 

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

For glomerular fibrin thrombi:

COMPARATIVE PATHOLOGY: 

REFERENCES: 

  1. Albretsen JC, Gwaltney-Brant SM, Khan SA. Evaluation of castor bean toxicosis in dogs: 98 cases. J Am Anim Hosp Assoc. 2000;36(3):229-233.
  2. Franz Dr, Jaax NK: Ricin toxin. In: Sidell RF, Takafuji ET, Franz DR, ed. Medical Aspects of Chemical and Biological Warfare. Washington DC: Office of the Surgeon General, TMM Publications; 1997:631-642.
  3. Hargis AM, Myers S. The Integument.  In: Zachary JF, ed. Pathological Basis of Veterinary Disease. 6th ed. Philadelphia, PA: Mosby Elsevier Inc.; 2017:1134.
  4. Humphreys DJ. Veterinary Toxicology. 3rd ed. London, England: Baillere Tindall.  1998;266-268.
  5. Roche JK, Stone MK, Gross LK, Linder M, Seaner R, Pincus SH, Obring TG. Post-exposure targeting of specific epitopes on ricin toxin abrogates toxin-induced hypoglycemia, hepatic injury and lethality in a mouse model. Laboratory Investigation; 2008;88:1178-1191.
  6. Roels, S, Coopman, V, Vanhaelen, P, Cordonnier, J. Lethal Ricin Intoxication in Two Adult Dogs: Toxocologic and Histopathologic Findings. J Vet Diagn Invest. 2010;22:466-468.
  7. Sebastian MM. Role of pathology in diagnosis. In: Gupta RC, ed. Veterinary Toxicology, Basic and Clinical Principles. Academic Press; 2007;1124.
  8. Uzal FA, Plattner BL, Hostetter JM. Alimentary system. In: Maxie MG, ed.  Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier; 2016:117, 163.
  9. Wilhelmsen CL and Pitt MLM. Lesions of acute inhaled lethal ricin intoxication in rhesus monkeys. Vet Pathol. 1996;33:296-302.
  10. Wong J, Korcheva V, Jacoby DB, Magun B. Intrapulmonary delivery of ricin at high dosage triggers a systemic inflammatory response and glomerular damage.  2007;170(5):1497-1509.
  11. Worbs, S, Kohler, K, Pauly, D, Avondet, M, Schaer, M, Dorner, M, Dorner, B. Ricinus communis Intoxications in Human and Veterianry Medicine—A Summary of Real Cases.   2011;3:1332-1372.

 

 


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