JPC SYSTEMIC PATHOLOGY
HEMOLYMPHATIC SYSTEM
April 2018
H-M01 (NP)

 

SIGNALMENT (JPC #1811021): Adult male dog

HISTORY: Blood smear from an adult male dog obtained for use by an investigator performing research in leukocyte chemotaxis. Screening test failed to give acceptable baseline results. White cell count - 14,300/ml. Hemogram from Coulter Model S+11 reported 88% lymphocytes, based on distribution of cell size.

HISTOPATHOLOGIC DESCRIPTION: Blood smear: The white and red cell counts appear adequate on this good quality smear. The differential count is: segmented neutrophils - 858 (6%), band neutrophils - 7150 (50%), monocytes - 3432 (24%), lymphocytes - 1859 (13%), and eosinophils - 1001 (7%). The predominant leukocyte type is the neutrophilic band cell. Over 90% of the granulocytes (neutrophils and eosinophils) have slightly indented round, band-shaped, or bilobed nuclei with smooth nuclear membranes and coarsely clumped (mature) chromatin. There are occasional polychromatophilic erythrocytes and platelet numbers are adequate.

MORPHOLOGIC DIAGNOSIS: Blood smear: Granulocytic hyposegmentation, diffuse, with mature chromatin pattern, breed unspecified, canine.

CONDITION: Pelger-Huët anomaly

GENERAL DISCUSSION: 

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS: None

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

 ADDITIONAL DIAGNOSTIC TESTS:

 DIFFERENTIAL DIAGNOSIS:

Other conditions that result in hyposegmented leukocytes in animals:

 References:

  1. Boes KM, Durham AC. Bone marrow, blood cells, and the lymphoid/lymphatic system. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby Elsevier; 2017:746.
  2. Bowles CA, Alsaker RD, Wolfle TL. Studies of the Pelger-Huët anomaly in foxhounds. Amer J of Pathol. 1979;96(1):237-245.
  3. Gill AF, Gaunt S, Sirninger J. Congenital Pelger-Huet anomaly in a horse. J Vet Clin Pathol. 2006;35(4):460-462.
  4. Harvey JW. Veterinary hematology: A diagnostic guide and color atlas. St Louis, MO: Elsevier Saunders; 2012:134-135.
  5. Latimer KS. Pelger-Huët anomaly. In: Feldman BV, Zinkl JG, Jain NC, eds. Schalm’s Veterinary Hematology. 5th ed. Baltimore, MD: Lippincott Williams and Wilkins; 2000:976-981.
  6. Latimer KS, Rowland GN, Mahaffey MB. Homozygous Pelger-Huët anomaly and chondrodysplasias in a stillborn kitten. Vet Pathol. 1988;25:325-328.
  7. Vale AM, Tomaz LR, Sousa RS, Soto-Blanco B. Pelger-Huët anomaly in two related mixed-breed dogs. J Vet Diagn Invest. 2011; 23(4):863-865.
  8. Valli, VEO, Kiupel M, et al. Hematopoietic system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:110.


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