JPC SYSTEMIC PATHOLOGY

INTEGUMENTARY SYSTEM

September 2013

I-M12

 

Signalment (JPC #1945775):  6-year-old female Yorkshire terrier

HISTORY:  This dog developed multiple skin nodules over an eight-month period.

HISTOPATHOLOGIC DESCRIPTION:  Haired skin (3 sections):  Expanding the deep dermis and subcutis; separating deep hair follicles and subcuticular adipocytes; and infiltrating the panniculs carnosus are multiple coalescing nodules composed of numerous epithelioid macrophages, neutrophils, lymphocytes, and fewer reactive fibroblasts with scant fibrous connective tissue.  This inflammatory infiltrate extends through the panniculus carnosus and often separates and surrounds skeletal muscle fibers, which are atrophied or occasionally swollen and pale with vacuolated sarcoplasm and loss of cross striations (degenerate).  In the less affected superficial dermis there are multifocal periadnexal and perivascular infiltrates of low numbers of lymphocytes and plasma cells with rare eosinophils, as well as dilated lymphatics and increased clear space separating collagen bundles (edema).  Few hair follicles in the superficial dermis are ectatic and filled with keratin.  Apocrine glands are mildly ectatic. 

MORPHOLOGIC DIAGNOSIS:  Haired skin and subcutis:  Panniculitis, nodular, granulomatous, multifocal to coalescing, marked, Yorkshire terrier, canine.

CONDITION:  Idiopathic sterile nodular panniculitis

GENERAL DISCUSSION:

PATHOGENENSIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS (nodular skin lesions):

 COMPARATIVE PATHOLOGY: 

 REFERENCES:

  1. Ginn PE, Mansell JEKL, Rakich PM: Skin and appendages. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 5th ed. Philadelphia, PA: Elsevier Saunders; 2007:745-746.
  2. Gross TL, Ihrke PJ, Walder EJ, et. al. Diseases of the panniculus. In: Gross TL, Ihrke PJ, Walder EJ,, eds. Skin Diseases of the Dog and Cat. 2nd ed. Ames, IA: Blackwell Science Ltd; 2005:548-551.
  3. Hargis AM, Ginn, PE. The integument. In: Zachary JF, McGavin MD, eds. Pathologic Basis of Veterinary Disease. 5th ed. St. Louis, MO: Elsevier Mosby; 2012:998,1075, 1077.
  4. O’Kell AL, Inteeworn N, Diaz SF, et. al. Canine sterile nodular panniculitis: A retrospective study of 14 Cases. J Vet Intern Med. 2010;24(2):278-284.
  1. Tham HL, Linder KE, Tucker A, Maggi R, Bizikova P. Protozoal nodular dermatitis and panniculitis in a rottweiler puppy caused by Caryospora biogenetic. Vet Dermatol. 2016;27(1):44-e12.
  2. Contreary CL, Outerbridge CA, Affolter VK, Kass PH, White SD. Canine sterile nodular panniculitis: A retrospective study of 39 dogs. Vet Dermatol. 2015;26(6):451-8.
  3. Rossi MA, Balakrishnan N, Linder KE, Messa JB, Breitschwerdt EB. Concurrent Bartonella henselae infection in a dog with panniculitis and owner with ulcerated nodular skin lesions. Vet Dermatol. 2015;26(1):60-3.


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