JPC SYSTEMIC PATHOLOGY
URINARY SYSTEM
December 2017
U-M08

Signalment (JPC #1952605):  Crowned pigeon

HISTORY:  Tissue from a very thin common crowned pigeon found down in its cage.  At necropsy, the bird had no subcutaneous fat stores, and there were white crystalline deposits on serosal surfaces throughout the coelomic cavity.

HISTOPATHOLOGIC DESCRIPTION:  Kidney (3 sections):  Multifocally and randomly, expanding and replacing tubules and extending into the adjacent cortical interstitium are colorless to basophilic radiating, sharp, acicular, crystalline deposits (urate tophi) up to 150 microns in diameter which are often surrounded by low to moderate numbers of viable and degenerate heterophils, fewer macrophages, and small amounts of eosinophilic cellular and karyorrhectic debris (necrosis), hemorrhage and fibrin, which extend into the adjacent interstitium.  Tubules exhibit one or more of the following changes: mild ectasia with attenuated epithelium; swollen epithelial cells with indistinct cell borders and microvacuolated cytoplasm (degeneration); hypereosinophilic epithelial cytoplasm and pyknotic nuclei (necrosis); or hypertrophic, crowded epithelial cells with prominent nuclei that have coarse chromatin and rare mitotic figures (regeneration).  Multifocally, tubular lumina contain sloughed necrotic epithelial cells admixed with heterophils and cellular debris (cellular casts), and affected tubules often have disruption of the tubule basement membrane (tubulorrhexis).  Randomly, the interstitium contains an infiltrate of few heterophils and occasional macrophages.

Liver (2 sections):  Multifocally and randomly, there are few previously described urate tophi surrounded by heterophils and macrophages. 

Spleen:  There are rare urate tophi as previously described. 

MORPHOLOGIC DIAGNOSIS:

Kidney:  Urate tophi with mild heterophilic and histiocytic interstitial nephritis, cellular casts, and tubular degeneration, necrosis, and regeneration, common crowned pigeon (Goura cristata), avian.

Liver:  Few urate tophi.

Spleen:  Rare urate tophi.

CONDITION:  Visceral gout (Visceral urate deposition); renal gout in chickens may also be referred to as urolithiasis, nephrosis and caged layer nephritis

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

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  2. Crespo R, Shivaprasad HL. Developmental, metabolic, and other noninfectious disorders. In: Swayne DE, ed. Diseases of Poultry. 12th ed. Ames, IA: John Wiley & Sons, Inc; 2013:1254-1256.
  3. Donoghue S. Nutrition. In: Mader DR, ed. Reptile Medicine and Surgery. 2nd ed. St. Louis, MO: Saunders Elsevier; 2006:281.
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  6. Ilha MR, Rajeev S. Pathology in practice. Mycotic dermatitis and gout in an American alligator. J Am Vet Med Assoc. 2015 Mar 15;246(6):609-11.
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  9. Ojkic D, Brash ML, Jackwood MW, Shivaprasad HL. Viral diseases. In: Boulianne M, ed. Avian Disease Manual. 7th Jacksonville, FL: The American Association of Avian Pathologists; 2013:29.
  10. Olson EJ, Carlson CS. Bones, joints, tendons, and ligaments. In: Zachary JF, McGavin MD, eds. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:1001.
  11. Shivaprasad HL. Fungal diseases. In: Boulianne M, ed. Avian Disease Manual. 7th Jacksonville, FL: The American Association of Avian Pathologists; 2013:148-149.
  12. Shivaprasad HL. Miscellaneous diseases. In: Boulianne M, ed. Avian Disease Manual. 7th Jacksonville, FL: The American Association of Avian Pathologists; 2013:222.
  13. Tripathi NK, Gregory CR, Latimer KS. Urinary system. In: Latimer KS, ed. Duncan & Prasse’s Veterinary Laboratory Medicine: Clinical Pathology. 5th ed. Ames, IA: Wiley-Blackwell; 2011:278.

 

 


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