JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
September 2018
D-N11

Signalment (JPC #4083908):  4-year-old Manx cat

HISTORY:  Right mandibular swelling

HISTOPATHOLOGIC DESCRIPTION:  Subcutis, right mandible:  Effacing and replacing the salivary gland, compressing adjacent salivary gland duct, and elevating the fibrovascular capsule is a multilobulated, unencapsulated, infiltrative, densely cellular neoplasm composed of polygonal cells arranged in islands, nests, packets, and short cords often forming glands, undergoing mucinous differentiation, on a dense fibrous to myxomatous, chondroid or schirrous stroma. Neoplastic cells have distinct cell borders, moderate amounts of brightly eosinophilic granular cytoplasm with few clear vacuoles, a round nucleus with finely stippled chromatin and 1-2 distinct nucleoli, or abundant amounts of microvacuolated cytoplasm and a compressed peripheralized nucleus with indistinct chromatin and nucleoli. Anisocytosis and anisokaryosis are moderate and there are 0-2 mitotic figures per 10 HPFs (2.37mm2). Glands often contain eosinophilic homogenous material (secretory product) admixed with erythrocytes, viable and degenerate neutrophils, and sloughed neoplastic cells. At the margins of the neoplasm there there are multifocal aggregates of perivascular lymphocytes and plasma cells, and small to moderate amounts of hemorrhage, fibrin, and edema with few hemosiderin-laden macrophages.  

MORPHOLOGIC DIAGNOSIS:  Subcutis, right mandible: Salivary adenocarcinoma, Manx, feline.

CONDITION:  Salivary adenocarcinoma

SYNONYM:  None

GENERAL DISCUSSION:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

Benign epithelial salivary gland neoplasia:

Malignant epithelial salivary gland neoplasia:

ULTRASTRUCTURE: 

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Delgado JB, Coimbra AAC, Santos-Cirqueira C, Sanches TC, et al. Parotid salivary gland basal cell adenocarcinoma in a big-eared opossum (Didelphis aurita). Comp. Path. 2018; 159:21-25.
  2. Gelberg HB. Alimentary system and the peritoneum, omentum, mesentery, and peritoneal cavity. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Elsevier; 2017:353.
  3. Kishimoto TE, Yoshimura H, Saito N, Michishita M, et al. Salivary gland epithelial-myoepithelial carcinoma with high-grade transformation in a dog. J Comp Path. 2015; 153(2-3):111-115.
  4. Munday JS, Lohr CV, Kiupel M. Tumors of the alimentary tract. In: Meuten DJ, ed. Tumors in Domestic Animals. 5th Ames, IA: John Wiley & Sons; 2017:544-549.
  5. Nakahira R, Michishita M, Kato M, Okuno Y, et al. Oncocytic carcinoma of the salivary gland in a dog. J Vet Diagn Invest. 2017; 29(1):105-108.
  6. Uzal FA, Plattner BL, Hostetter JM. Alimentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer's Pathology of Domestic Animals. Vol 2. 6th ed. Philadelphia, PA: Saunders Elsevier; 2016:30.


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