JPC SYSTEMIC PATHOLOGY

INTEGUMENTARY SYSTEM

September 2016

I-M32

 

Signalment (JPC 2614951):  Nine-year-old domestic shorthair cat

HISTORY:  This cat had a swollen, soft, discolored footpad.

HISTOPATHOLOGIC DESCRIPTION:  Skin, footpad:  Multifocally infiltrating the dermis, separating and surrounding footpad adipose tissue and collagen bundles, and surrounding adjacent adnexa are numerous plasma cells and fewer lymphocytes and neutrophils.  Frequently, plasma cells are packed with globular eosinophilic intracytoplasmic vacuoles (Russell bodies within Mott cells). There is increased clear space separating collagen fibers and ectatic lymphatics (edema) which occasionally contain aggregates of lymphocytes.  There is minimal multifocal epidermal spongiosis characterized by increased intercellular clear space and accentuation of intercellular bridges. 

MORPHOLOGIC DIAGNOSIS:  Skin, footpad:  Pododermatitis, plasmacytic, diffuse, marked, domestic shorthair, feline.

CAUSE:  Unknown

CONDITION:  Feline plasma cell pododermatitis

GENERAL DISCUSSION: 

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

REFERENCES:

  1. Bettenay SV, Lappin MR, Meuller. An immunohistochemical and polymerase chain reaction evaluation of feline plasmacytic pododermatitis. Vet Pathol. 2007;44(1):80-83
  2. Breathnach, R.M., Baker, K.P., Quinn, P.J., McGeady, T.A., Aherne, C.M., and Jones, B.R. Clinical, immunological and histopathological findings in a subpopulation of dogs with pododermatitis. Veterinary Dermatology. 2005:16:364–372.
  3. Dias Pereira P. Faustino, AMR. Feline plasma cell pododermatitis: a study of 8 cases. Veterinary Dermatology. 2003:14: 333–337.
  4. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Diseases of the dermis. In: Skin Diseases of the Dog and Cat. 2nd ed. Ames, IA: Blackwell; 2005:363-364.
  5. Guaguere E, Hubert B, Delabre C. Feline pododermatoses. Vet Dermatol. 1992;3(1):1-12.
  6. Mauldin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG Jubb, Kennedy,and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA: Elsevier Ltd. 2016:613-614.
  7. Pereira PD, Faustino AM. Feline plasma cell pododermatitis: A study of 8 cases. Vet Dermatol. 2003;14:333-337.
  8. Scott DW, Miller WH, Griffin CE. Miscellaneous skin diseases. In: Small Animal Dermatology.7th ed. Philadelphia, PA: WB Saunders Co; 2013: 718-719.


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