JPC SYSTEMIC PATHOLOGY
HEMOLYMPHATIC SYSTEM
April 2018
H-N04 (NP)

Signalment (AFIP #3167242):  Female chicken

HISTORY:  None.

HISTOPATHOLOGIC DESCRIPTION:  Liver:  Focally extensively expanding the hepatic parenchyma up to 10 mm and compressing adjacent hepatocytes is an unencapsulated, multilobular, moderately cellular, well demarcated neoplasm composed of mature adipocytes and variable numbers of hematopoietic cells, in various stages of maturation, arranged in sheets on a scant fibrovascular stroma. Both progenitor and precursor cells are represented. There are also abundant mature red blood cells admixed with small amounts of eosinophilic proteinaceous fluid and scattered, golden to dark brown pigment-laden macrophages. Cellular atypia is minimal and mitotic figures are rare (<1 per 10 HPF).  Focally within the neoplasm there is formation of immature woven bone (osseous metaplasia).  Hepatocytes adjacent to the neoplasm are often degenerate (swollen, vacuolated cytoplasm), shrunken and atrophied, or lost with dissociation of hepatic cords.  Multifocally low numbers of lymphocytes, histiocytes and heterophils expand the periportal regions and extend into adjacent parenchyma. 

MORPHOLOGIC DIAGNOSIS:  Liver: Myelolipoma, chicken, avian.

GENERAL DISCUSSION:

PATHOGENESIS: 

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY: 

REFERENCES: 

  1. Carillo JD, Boza S, Soler M, et al.  What is your diagnosis? Splenic myelolipoma.  J Am Vet Med Assoc.  2012;240(4):375-376.
  2. Cullen JM, Stalker MJ.  Liver and biliary system. In:  Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. St. Louis, MO: Elsevier Limited; 2016:350-351.
  3. Hatai H, Ochiai K, Nakamura S, et al.  Hepatic myelolipoma and amyloidosis with osseous metaplasia in a swan goose (Anser cygnoides).  J Comp Path.  2009;141(4):260-264.
  4. Kleinschmidt LM, Langan JN, Warneke MR, et al.  Retrospective review of the prevalence of myelolipoma in Goeldi’s monkeys (Callimico goeldii).  J Zoo Wildl Med.  2015;46(2):273-278.
  5. Latimer KS, Rakich PM.  Subcutaneous and hepatic myelolipomas in four exotic birds.  Vet Pathol.  1995;32(1):84-87.
  6. Munson L, Nesbit JW, Meltzer DG, et al.  Diseases of captive cheetahs (Acinonyx jubatus jubatus) in South Africa: a 20-year retrospective survey.  J Zoo Wildl Med.  1999;30(3):342-347.
  7. Newman, SJ, Inzana K, Chickering W.  Extradural myelolipoma in a dog.  J Vet Diagn Invest.  200 Jan;12(1):71-74.
  8. Ozakt K, Kinoshita H, Kurasho H, Narama I.  Cutaneous myelolipoma in a peach-faced lovebird (Agapornis roseicollis).  Avian Pathol.  1996;25(1):131-4.
  9. Rosol TJ, Groene A.  Endocrine glands. In:  Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier Limited; 2016:343-344.
  10. Storms G, Janssens G. Intraocular myelolipoma in a dog.  Vet Ophthalmol.  2013 Jul;16 Suppl 1:183-7.
  11. Thomas RM, Fischetti AJ.  What is your diagnosis? Myelolipoma.  J Am Vet Med Assoc.  2012;241(7):881-883.
  12. Valli VE, Bienzle D, Meuten DJ. Tumors of the hemolymphatic systems.  In: Meuten DJ, ed. Tumors in Domestic Animals. 5th ed. Wiley Blackwell, Ames, IA, 2017:317-318.


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