April 2019

Signalment (JPC #1948332):  13-year-old male Labrador retriever


HISTOPATHOLOGIC DESCRIPTION:  Heart:  Diffusely, the lumina of large elastic and muscular coronary arteries are narrowed or occluded by thickened vessel walls.  The internal elastic lamina is disrupted / discontinuous and the tunica intima and tunica media are markedly disorganized and expanded by multifocal to coalescing aggregates of lipid-laden macrophages with abundant foamy, microvacuolated cytoplasm (foam cells), numerous acicular cholesterol clefts (extracellular lipid), amphophilic granular cellular debris, mineral, hypertrophic smooth muscle cells and small amounts of fibrous connective tissue (the latter two within the tunica media) .  The tunica adventitia is expanded by fibrous connective tissue and low numbers of lymphocytes, plasma cells and fewer macrophages that infiltrate into adjacent fibroadipose tissue.

MORPHOLOGIC DIAGNOSIS:  Heart, coronary arteries:  Atherosclerosis, diffuse, severe, with intimal and medial foam cells, cholesterol clefts, mineralization and smooth muscle hypertrophy, Labrador retriever, canine.

CONDITION:  Atherosclerosis











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