JPC SYSTEMIC PATHOLOGY

INTEGUMENTATY SYSTEM

October 2016

I-N20 (NP)

 

Signalment (JPC#1718684):  Age and breed unspecified dog.

HISTORY:  Dog presented with a reddened plaque-like growth involving the skin of the scrotum.

HISTOPATHOLOGIC DESCRIPTION:  Haired skin, scrotum:  Expanding the dermis is an unencapsulated, well-demarcated, 4 x 8 mm mass composed of densely packed, randomly arranged streams and bundles of plump spindle cells that form well-differentiated, variably sized, blood filled, vascular channels lined by endothelium and surrounded by smooth muscle and collagen bundles.  The spindle cells have variably distinct borders, moderate amounts of finely fibrillar, pale eosinophilic cytoplasm, elongate nuclei with finely stippled chromatin, and a single magenta nucleolus.  Mitotic figures are not observed.  Blood vessels within the mass are lined by endothelium with rounded nuclei, and larger centrally oriented vessels are often filled with erythrocytes, abundant fibrin, and aggregates of neutrophils.  Multifocally, there are predominately perivascular aggregates of degenerative neutrophils.  The epidermis is mildly hyperplastic, pigmented, and contains moderate amounts of orthokeratotic hyperkeratosis with a loss of adjacent adnexal structures.  Occasionally lymphatics of the superficial dermis are ectatic and collagen bundles are separated by clear space (edema).

MORPHOLOGIC DIAGNOSIS:  Haired skin, scrotum (per contributor):  Vascular hamartoma, breed unspecified, canine.

 

GENERAL DISCUSSION: 

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

DIFFERENTIAL DIAGNOSIS: 

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Borel N, Grest P, Junge H, Wehrli Eser M. Vascular hamartoma in the central nervous system of a foal. J Vet Diagn Invest. 2014;26(6):805-9.
  2. Goldschmidt MH, Dunstan RW, Stannard AA, von Tscharner C, Walder EJ, Yager JA. Histologic Classification of Epithelial and Melanocytic Tumors of the Skin of Domestic Animals. Washington DC: Armed Forces Institute of Pathology; 1998:35-36.
  3. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Mesenchymal neoplasm and other tumors. In: Skin Diseases of the Dog and Cat Clinical and Histopathologic Diagnosis. 2nd ed., Ames, IA: Blackwell Science Ltd.; 2005:738-739.
  4. Hargis AM, Myers S. The integument. In: Zachary JF, eds. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Mosby Inc.; 2016: 289, 1119.
  5. Mauldin EA, Peters-Kennedy J. Integumentary system.  In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 2. 6th ed. New York, NY: Elsevier Limited; 2015:703,705.
  6. Meuten DJ. Tumors in Domestic Animals. 4th ed., Ames, IA: Iowa State Press; 2002:104,214-215, 556,729.
  7. Miller WH, Griffin CE, Campbell KL. Muller and Kirk's Small Animal Dermatology. 7th ed., Philadelphia, PA: WB Saunders Company; 2012:828.
  8. Shirota M, Kawashima J, Nakamura T, Ogawa Y, Kamiie J, Shirota K. Vascular hamartoma in the uterus of a female Sprague-Dawley rat with an episode of vaginal bleeding. Toxicol Pathol. 2013;41(7):1011-5.
  9. Smith SH, Winkle TV. Cerebral vascular hamartomas in five dogs. Vet Pathol. 2001;38:108-112.
  10. Sugiyama A, Ozaki K, Takeuchi T, Narama I. Cardiac vascular hamartoma in two slaughtered cattle. J Comp Path. 2007;136:202-205.


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