JPC SYSTEMIC PATHOLOGY

INTEGUMENTRY SYSTEM

October 2016

I-N26

 

Signalment (JPC #2776270):  A dog

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Haired skin:  Effacing dermal collagen and adnexa, elevating the epidermis, infiltrating the epidermal and follicular epithelium, and extending into the subcutis and panniculus carnosus is an unencapsulated, infiltrative, poorly demarcated, densely cellular neoplasm composed of round cells arranged in sheets on a preexisting fibrovascular stroma.  Neoplastic cells have indistinct cell borders, a moderate amount of eosinophilic cytoplasm, and irregularly round nuclei, with finely stippled chromatin, and one generally distinct nucleolus.  The mitotic rate averages 2 per 40X HPF. Anisocytosis and anisokaryosis are marked. Within the epidermis are clusters of intraepithelial neoplastic lymphocytes surrounded by clear space (Pautrier’s microabscesses) Diffusely within the superficial dermis there is abundant edema, hemorrhage and degenerate and non-degenerate neutrophils. The epidermis is focally ulcerated and replaced with a serocellular crust and has diffuse parakeratotic hyperkeratosis, multifocal intracorneal pustules, and epidermal hyperplasia (acanthosis).

MORPHOLOGIC DIAGNOSIS:  Haired skin:  Epitheliotropic lymphoma, breed unspecified, canine.

SYNONYMS:  Mycosis fungoides, epitheliotropic T-cell lymphoma

GENERAL DISCUSSION:

 

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Brachelente C, Affolter VK, et al. CD3 and CD20 coexpression in a case of canine cutaneous epitheliotropic T-cell lymphoma (mycosis fungoides). Vet Pathol. 2016;53(3):563-566.
  2. Chimura N, Iio A, et al. Transcription profile of chemokine receptors, cytokines and cytotoxic markers in peripheral blood of dogs with epitheliotropic cutaneous lymphoma.  Vet Dermatol.  2013;24:629-e155.
  3. Chung T-H, Kim H-J, Choi, U-S. Multicentric epitheliotroic T-cell lymphoma in an African hedgehog (Atelerix albiventris).  Vet Clin Pathol.  2014;43(3):601-604.
  4. Fontaine J, Bovens C, Bettenay S, Mueller RS. Canine cutaneous epitheliotropic T-cell lymphoma: a review. Vet Comp Oncol. 2009;(7):1-14.
  5. Fontaine J, Heimann M, Day MJ. Canine cutaneous epitheliotropic T-cell lymphoma: A review of 30 cases. Vet Dermatol. 2010;(21):267-275.
  6. Mauldin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA: Elsevier; 2015:733-735.
  7. Gross TL, Ihrke PJ, Walder EJ, et. Lymphocytic tumors. In: Gross TL, Ihrke PJ, Walder EJ, et al., Skin Diseases of the Dog and Cat. 2nd ed. Ames, IA: Blackwell Science Ltd; 2005:876-882.
  8. Hasbach AE, Stern, AW. Pagetoid reticulosis (epitheliotropic cutaneous T-cell lymphoma) in an adult alpaca (Vicugna pacos).  J Vet Diagn Invest.  2016;28(4):469-472.
  9. Higbie CT, Carpenter JW, et al. Cutaneous epitheliotropic T-cell lymphoma with metastases in a Virginia opossum (Didelphis virginiana). J Zoo Wildl Med.  2015;46(2):409-413.
  10. Koebrich S, Grest P, Favrot C, Wilhelm, S. Epitheliotropic T-cell lymphoma in a guinea pig. Vet Dermatol. 2011:22(2):215-219.
  11. Miller CA, Durham AC, et al. Classification and clinical features in 88 cases of equine cutaneous lymphoma.  J Vet Diagn Invest.  2015;27(1):86-91.
  12. Mineshige T, Kawarai S, et al. Cutaneous epitheliotropic T-cell lymphoma with systemic dissemination in a dog.  J Vet Diagn Invest. 2016;28(3):327-331.
  13. Moore PF, Affolter, VK, Graha, PS, Hirt B. Canine epitheliotropic cutaneous T-cell lymphoma: An investigation of T-cell receptor immunophenotype, lesion topography and molecular clonality. Vet Dermatol. 2009:20(5):569-576.
  14. Ramos-Varal JA, Miller MA. Immunohistochemical expression of E-cadherin does not distinguish canine cutaneous histiocytoma from other canine round cell tumors. Vet Pathol. 2011:(48)3:758-756.
  15. Scott DW, Miller WH, Griffin CE. Neoplastic and non-neoplastic tumors. In: Scott DW, Miller WH, Griffin CE eds. Small Animal Dermatology, 6th ed. Philadelphia, PA: WB Saunders Company; 2001:1331.


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