JPC SYSTEMIC PATHOLOGY

INTEGUMENTARY SYSTEM

October 2016

I-N34

 

Signalment (V04-14822):  Tissue from a cat

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Haired skin and bone, digit: Expanding the dermis, elevating the overlying multifocally hyperplastic epidermis and infiltrating the bone is an unencapsulated, poorly demarcated moderately cellular neoplasm composed of respiratory epithelial cells arranged in islands and acini on a dense desmoplastic stroma.  Neoplastic cells are columnar to cuboidal with cilia lining their apical surface, they have distinct cell borders, a moderate amount of eosinophilic granular cytoplasm, a round to oval nucleus that is located on the basilar surface with finely stippled chromatin and one distinct nucleolus.  There is moderate anisocytosis and anisokaryosis.  The mitotic count is 2 per 10 HPF.  Multifocally within the neoplasm there is single cells necrosis.  There is a focally extensive area in the superficial dermis composed of increased numbers of small caliber blood vessels that are oriented perpendicular to the epidermis admixed with occasional neutrophils and separated by clear space (edema) (granulation tissue).  The overlying epidermis is moderately hyperplastic with acanthosis, spongiosis and rete ridge formation.      

MORPHOLOGIC DIAGNOSIS:  Haired skin and bone:  Metastatic pulmonary carcinoma, feline.

DISEASE: Lung-digit syndrome

GENERAL DISCUSSION: 

TYPICAL CLINICAL FINDINGS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS:

Gross:

Histologic:

COMPARATIVE PATHOLOGY: 

REFERENCES: 

  1. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Skin diseases of the dog and cat. 2nd ed., Oxford, UK: Blackwell Science; 2005: 706.
  2. Mauldin EA, Peters-Kennedy J. Integumentary system.  In: Maxie MG, ed. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA: Elsevier Ltd; 2016:736.
  3. Petterino C, Guazzi P, Ferro S, Castagnaro. Bronchogenic adenocarcinoma in a cat: An unusual case of metastasis to the skin.  Vet Clin Pathol.  2005;34:401-404.
  4. Schaffer PA, Barnes S. Pathology in practice.  2016;249(2):157-160.
  5. Vobornik S, Johnson M, Diesel A, Simpler R. What is your diagnosis? Aspirate from a digit in a cat.  Vet Clin Pathol.  2014;43(2):291-292.
  6. Wobeser BK, Kidney BA, Powers BE, Winthro SJ, Mayer MN, Spinato MT, Allen AL. Diagnoses and clinical outcomes associated with surgically amputated feline digits submitted to multiple diagnostic laboratories.  Vet Pathol.  2007;44:362-365.


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