JPC SYSTEMIC PATHOLOGY

INTEGUMENTARY SYSTEM

September 2016

I-M15 (NP)

 

Signalment (JPC #2237039):  2-year-old shar-pei

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Haired skin:  Diffusely, throughout the dermis, collagen bundles are fragmented, distorted, and widely separated by abundant, wispy, amphophilic material (mucin) and increased clear space (edema) admixed with few neutrophils, macrophages, lymphocytes and plasma cells.  Multifocally, within the superficial dermis, few macrophages contain melanin granules (pigmentary incontinence).  There is minimal hyperplasia and hyperkeratosis of follicular epithelium.  Diffusely, the epidermis is mildly hyperplastic with short rete ridges.

MORPHOLOGIC DIAGNOSIS:  Haired skin, dermis:  Mucinosis, diffuse, moderate, with minimal, chronic-active dermatitis, Chinese shar-pei, canine.

CONDITION:  Cutaneous mucinosis

SYNONYMS:  Idiopathic mucinosis, congenital myxedema

GENERAL DISCUSSION: 

PATHOGENESIS: 

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS: 

ULTRASTRUCTURAL FINDINGS: 

ADDITIONAL DIAGNOSTIC TESTS: 

DIFFERENTIAL DIAGNOSIS: 

COMPARATIVE PATHOLOGY: 

REFERENCES: 

  1. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Skin Diseases of the Dog and Cat, Clinical and Histopathologic Diagnosis. 2nd ed. Ames Iowa: Blackwell Publishing; 2005:380-383.
  2. Mauldin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Edinburgh, England: Elsevier; 2016:522-523.
  3. Momoto Y, Yamamoto M, Yoshimastu H, Satoshi N, Shigihara K, Yasuda A, Hayakawa N, Ikezawa M, Tani, K, Mori A, Sako T. Nodular cutaneous mucinosis in a hypothyroid dog- a severe form of myxedema. Vet Derm. 2016; 27:61-63.
  4. Palmieri C, Anthenill L, Sjivaprasad HL. Cutaneous mucinosis in a strain of brown-egg laying chickens.  Vet Pathol.2015;52(2):351-355.
  5. Scott DW, Miller WH, Griffin CE. Muller and Kirk’s Small Animal Dermatology. 6th ed., Philadelphia, PA: W.B Saunders; 2001:996-997. 


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