JPC SYSTEMIC PATHOLOGY
REPRODUCTIVE SYSTEM
January 2019 R-N01

Signalment (JPC #1688540):  Dog

HISTORY:  None

HISTOPATHOLOGIC DESCRIPTION:  Penis:  Focally extensively expanding the superficial subepithelial connective tissue and effacing the overlying mucosa is a broad-based, exophytic, unencapsulated, well-demarcated neoplasm composed of sheets of closely-packed round cells multifocally separated by fine strands of fibrous connective tissue. Neoplastic cells have distinct cell borders, moderate amount of pale eosinophilic, finely granular to clear cytoplasm, and a central, round nucleus with coarsely-stippled chromatin and one prominent, magenta nucleolus. The mitotic rate averages 3/10 HPF. There is a focally extensive area of necrosis, characterized by a loss of cellular detail, increased cytoplasmic eosinophilia, and scattered eosinophilic cellular and karyorrhectic debris. Scattered throughout the neoplasm and perivascularly within the adjacent subepithelial connective tissue are few infiltrating lymphocytes and plasma cells and rare eosinophils and hemosiderin-laden macrophages. Neoplastic cells focally compress the lumina of subjacent vessels.

MORPHOLOGIC DIAGNOSIS:  Penis:  Transmissible venereal tumor (TVT), breed unspecified, canine

SYNONYMS:  Sticker’s sarcoma, venereal lymphosarcoma, venereal histiocytoma, venereal granuloma, transmissible sarcoma

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURAL FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

Other canine external genital and/or round cell neoplasms:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. Agnew DW, MacLachlan NJ. Tumors of the genital system. In: Meuten DJ, ed. Tumors in Domestic Animals. 5th Ames, IA: John Wiley & Sons; 2017:718-721.
  2. Foster RA. Female reproductive system and mammae. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:1190-1191.
  3. Foster RA. Male genital system. In: Maxie MG, ed. Jubb, Kennedy, and Palmers Pathology of Domestic Animals. Vol 3. 6th ed. St Louis, MO: Elsevier; 2016:509-510.
  4. Foster RA. Male reproductive system. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th ed. St. Louis, MO: Elsevier; 2017:1221-1222.
  5. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Skin Diseases of the Dog and Cat. 2nd ed. Oxford, UK: Blackwell Publishing; 2005:800-803.
  6. Kegler K, Habierski A, Hahn K, Amarilla SP, Seehusen F, Baumgärtner W. Vaginal canine transmissible venereal tumour associated with intra-tumoural Leishmania spp. amastigotes in an asymptomatic female dog. J Comp Pathol. 2013 Aug-Oct;149(2-3):156-161.
  7. Komnenou AT, Thomas AL, Kyriazis AP, Poutahidis T, Papzoglou LG. Ocular manifestations of canine transmissible venereal tumour: a retrospective study of 25 cases in Greece. Vet Rec. 2015; 176(20):523-528.
  8. Pye RJ, Woods GM, Kreiss A. Devil Facial Tumor Disease. Vet Pathol. 2016 Jul;53(4):726-736.
  9. Schlafer DH, Foster RA. Female genital system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 3. 6th ed. St. Louis, MO: Elsevier; 2016:448-449.
  10. Tovar C, Obendorf D, Murchison EP, et al. Tumor-pecific diagnostic marker for transmissible facial tumors of Tasmanian devils: Immunohistochemistry studies. Vet Pathol. 2011;48(6):1195-1203.


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