JPC SYSTEMIC PATHOLOGY
SPECIAL SENSES
April 2018
S-M14 (NP)

Signalment (JPC #1690931):  A ten-year-old Siamese cat

HISTORY:  This cat had a black spot on one eye for approximately one year.  The spot was surgically removed.  A similar spot had been removed three years previously.

HISTOPATHOLOGIC DESCRIPTION:  Cornea:  Over 90% of the stroma is composed of hyalinized, golden brown to eosinophilic, acellular material that retains tissue architecture (stromal coagulative necrosis).  In the affected area there is diffuse loss of epithelium and endothelium and multifocal loss of Descemet’s membrane.  There are multifocal depressions along the surface that occasionally extend into the deep stroma.  In the remaining area of the cornea, there is a focal loss of epithelium (ulcer) and clear space separating stromal fibers (edema).

MORPHOLOGIC DIAGNOSIS:  Cornea:  Necrosis, coagulative, focally extensive, with pigmentation and loss of epithelium (sequestrum), and ulceration, Siamese, feline.

CAUSE:  Unknown

CONDITION:  Corneal sequestrum

SYNONYMS:  Corneal black spot, corneal mummification, corneal nigrum, superficial stromal sequestration, focal corneal degeneration

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS: 

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ULTRASTRUCTURE

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY: 

REFERENCES:

  1. Dubielzig RR, Ketring KL, McLellan GJ, et al. eds. Veterinary Ocular Pathology: A Comparative Review. St. Louis, MO: Elsevier Saunders; 2010: 216-219.
  2. Dubin AJ, Pizzirani S, Beamer GL. Corneal sequestrum in a dog with chronic unilateral keratoconjunctivitis sicca. J Am Vet Med Assoc. 2013;243(12):1751-1755.
  3. Gelatt KN, Plummer CE. Color Atlas of Veterinary Ophthalmology. 2nd Ames, IA: Wiley Blackwell; 2017:36-37, 40, 249-253
  4. Labelle P. The eye. In: Zachary JF, ed. Pathologic Basis of Veterinary Disease. 6th St. Louis, MO: Elsevier; 2017: 1298
  5. Wilcock BP, Njaa BL. Special senses. In: Maxie MG, ed. Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals. Vol 1. 6th St. Louis, MO: Elsevier; 2016:434,


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